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A device and method for comparative analysis of effects of different blood anticoagulants

A blood anticoagulant, comparative analysis technology, applied in transmittance measurement and other directions, can solve problems such as poor definition

Inactive Publication Date: 2017-02-22
韩希芹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in general, how to characterize the performance of anticoagulants and their effects on blood samples is not well defined. The previous method is often to measure the results of whole blood analysis and compare them with more general anticoagulants, such as EDTA-K2, but The duration of anticoagulation, whether it has changed, is not easy to define
There are also blood sample detection values, such as WBC and PLT values, but these parameters are difficult to intuitively or comprehensively explain the strength of anticoagulant properties

Method used

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  • A device and method for comparative analysis of effects of different blood anticoagulants
  • A device and method for comparative analysis of effects of different blood anticoagulants
  • A device and method for comparative analysis of effects of different blood anticoagulants

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Experimental program
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Effect test

Embodiment 1

[0044] A device for comparative analysis of the effects of different blood anticoagulants, which includes a light source array, a detector array, a detection rack, a sample tube, a sample tube holder, a detection lifting system, a control module, and a PC;

[0045] The detection and lifting system consists of a horizontal bracket, a lifting screw, a vertical guide rail, a support rod, a supporting top seat, a lifting base, a lifting seat, and a stepping motor. The stepping motor is connected to the control module by communication, and the stepping motor also has a governor. , directly controlled by the PC through the control module;

[0046] The light source array is composed of multiple monochromatic light sources arranged in a row;

[0047] The detector array is composed of multiple detectors, and each monochromatic light source is directly opposite to a detector on a horizontal line across a sample tube;

[0048] There is also an optical path use module, which is controlle...

Embodiment 2

[0071] The difference between the implementation of Example 2 and Example 1 is that the wavelength of the monochromatic light source used is 670nm, and the four mixed anticoagulants added to the blood sample sources A and B are EDTA-K2, heparin sodium, citron Sodium oxalate, potassium oxalate, and sodium citrate are all mixed with an anticoagulant in a ratio of 1:4. The concentration of the anticoagulant is added to the general concentration of the anticoagulant. After 6 hours of transmittance scanning, step 3) can be carried out again. Scanning, and forming an image of the scanning data, and comparing with the image formed of the scanning data of the same sample 6 hours ago, to determine the change of the layer gap, thereby further determining the change of the anticoagulant performance. Except for the blood sample added with EDTA-K2 and potassium oxalate 1:4 anticoagulant, the boundary of blood component stratification was slightly blurred after 6 hours, and other changes wer...

Embodiment 3

[0073]The difference between the implementation of Example 3 and Example 2 is that the wavelength of the monochromatic light source used is 690nm, and the mixed anticoagulants added in the blood sample sources A and B are respectively EDTA-K2 and heparin sodium 1:4, 1: 6, and the anticoagulant mixed with EDTA-K2 and lithium heparin at a ratio of 1:5, 1:9, the concentration of the anticoagulant is added to the general concentration of the anticoagulant, and step 3 can be performed again after 6 hours of the transmittance scan ), and image the scan data, and compare it with the image formed by the scan data of the same sample 6 hours ago to determine the change of the layer gap, thereby further determining the change of the anticoagulant performance. Through the comparison of blood sample transmittance images and observation after magnification, it was found that the blood sample added with anticoagulant mixed with EDTA-K2 and lithium heparin had a clearer boundary of blood sampl...

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Abstract

The invention provides a method and device. The degree of the anticoagulation performance can be defined according to the blood layering situation and the blood pressure integral value. In the preferable embodiment, whether the layering boundary of a centrifugal blood component is clear or not can be seen more clearly under the situation that the lifting degree slows down. By means of the device, certain photoelectric and computing devices are utilized in a supplementary mode, a plurality of samples can be measured at the same time, results are obtained, the results obtained when the same anticoagulant is used in different blood samples and different anticoagulants are used in the same blood sample can be compared at the same time, and an obvious practical support function is provided for the clinical examination and the medical science analysis and research related to the anticoagulant study.

Description

technical field [0001] The invention relates to the field of property analysis of anticoagulants, in particular to a device and method for comparative analysis of the effects of different blood anticoagulants. Background technique [0002] Because the original blood sample is a non-Newtonian fluid and is prone to agglutination, it is necessary to add an anticoagulant to resist the agglutination of the blood sample when doing various blood component analysis and whole blood analysis. However, the performance of anticoagulants is different, and the blood samples added with different anticoagulants have different test conditions and requirements. For whole blood cell analysis, the recommended EDTA-K2 is generally used, but if the test blood sample requires a long anticoagulant time, heparin sodium, heparin lithium, or sodium citrate can be appropriately added in proportion to strengthen anticoagulation Time to adapt to different blood sample testing needs. But in general, how...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/59
Inventor 韩希芹陈玉梅
Owner 韩希芹