Pharmaceutical composition for treating ureteral calculi and application of pharmaceutical composition

A technology for ureteral calculi and composition, applied in the field of traditional Chinese medicine, can solve the problems of long discharge time of calculi, prone to complications, aggravated renal colic, etc., and achieves the advantages of less complications, alleviation of renal colic and mucosal edema. Effect

Inactive Publication Date: 2015-05-06
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment of ureteral calculi is mainly conservative treatment. Conservative treatment includes exercise, drinking more water, anti-inflammation, detumescence, traditional Chinese medicine and symptomatic treatment, etc. However, it takes a long time for stones to pass out, complications are prone to occur, and the curative effect is not good
At present, most of the stone-dispelling drugs are Chinese patent preparations, but the general Chinese patent medicines can expel stones for about 3 weeks. During the stone-dispelling period, the renal colic intensifies, and patients often require other treatments because they cannot tolerate them.

Method used

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  • Pharmaceutical composition for treating ureteral calculi and application of pharmaceutical composition
  • Pharmaceutical composition for treating ureteral calculi and application of pharmaceutical composition
  • Pharmaceutical composition for treating ureteral calculi and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1 Preparation of Chinese medicine dry cream powder

[0013] Weigh 0.60 kg of weeping willow leaves, 0.05 kg of cicada slough, 0.30 kg of sage grass and 0.25 kg of talcum powder in the prescribed amount, mix them, add 15 L of water and heat to boiling, filter after boiling for 2 hours, collect the filtrate for the first time, and the dregs for subsequent use; Add 12L of water to the dregs, heat to boiling, keep boiling for 2 hours, filter, and collect the second filtrate; combine the first and second filtrates, filter with four layers of filter cloth, remove insoluble matter, collect the filtrate, and centrifuge at 3000rpm for 15min , the supernatant was spray-dried, the inlet temperature was 120°C, the outlet temperature was 65°C, the feed rate was 3ml / min, the air extraction rate was 400L / h, and pulverized to obtain dry cream powder.

Embodiment 2

[0014] The preparation of embodiment 2 dispersible tablet

[0015] Tablet prescription:

[0016]

[0017]

[0018] Preparation Process:

[0019] Get the dry paste powder of Chinese medicine prepared in Example 1, pass through a 100-mesh sieve, and pass through an 80-mesh sieve for other auxiliary materials, take by weighing the dry paste powder of traditional Chinese medicine and the vitamin C, cross-linked polyvinylpyrrolidone and microcrystalline cellulose of the prescription amount, Mix well, add 5% PVP K30 absolute ethanol solution to granulate, dry, add the prescribed amount of magnesium stearate, mix evenly, compress 1000 tablets, and obtain (specification: each tablet contains 20 mg of traditional Chinese medicine dry paste powder).

Embodiment 3

[0020] Embodiment 3 The clinical application of the medicine of the present invention to patients with ureteral calculi

[0021] Eighty-six patients with lower ureteral calculi were diagnosed as single lower ureteral calculus with a diameter of 0.4 to 1.0 cm after B-ultrasound, KUB and IVP examinations. Among them, there were 52 males and 34 females; the average age was 40.1±6.9 years old. They were randomly divided into the control group and the test group, 43 cases in each group. There was no significant difference in the general data between the two groups (P>0.05), which were comparable.

[0022] The control group took tamsulosin hydrochloride sustained-release capsules (manufactured by Astellas Pharmaceuticals, specification 0.2mg / capsule), 1 time / d, capsules / time, orally. The test group took traditional Chinese medicine dispersible tablets prepared according to the prescription process of Example 2 of the present invention, 2 times / d, 3 tablets / time, orally. During the...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating ureteral calculi and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following traditional Chinese raw materials in parts by weight: 50-70 parts of weeping willow leaf, 3-6 parts of cicada molting, 20-40 parts of cudweed and 18-33 parts of talcum. The pharmaceutical composition disclosed by the invention can relieve swelling of ureteral mucosa, promote absorption of inflammation and stone-dissolving, meanwhile, the pharmaceutical composition can also ensure that the ureter is loose, accelerate the calculus expel from bodies of patients, relieve renal colic obviously at the same time, and is few in complications.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating ureteral calculus and its application. Background technique [0002] Urolithiasis is a common disease that endangers human health today. The main clinical symptoms are renal colic, hematuria, and distending pain. When colic occurs, there may be restlessness, nausea and vomiting, etc. If secondary infection occurs, there may be symptoms of urinary tract irritation such as frequent urination, urgency, and painful urination. Ureteral calculus is colic pain at the location of the calculus. The pain radiates to the inner thigh and groin. Men can radiate pain to the penis and scrotum, and women can radiate pain to the labia. Bladder stones are characterized by pain in the lower abdomen, radiating to the vulva and perineum, and interruption of urination. The treatment for ureteral calculi is mainly conservative...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/76A61P13/04A61P13/12A61K35/64A61K33/12
Inventor 张欣红王蕊马玉容杨静
Owner QINGDAO MUNICIPAL HOSPITAL
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