Compound hypotensive tablet and preparation method thereof

A kind of technology of triamterene and reserpine, applied in the field of medicine

Active Publication Date: 2015-05-27
CHINA RESOURCES DOUBLE CRANE PHARMA COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Finally, from the perspective of pharmacoeconomics, the price of domestic fixed-dose compound preparations is relatively low. For my country, a country with poor health resources and as many as 100 million hypertensive patients, Beijing Antihypertensive No. 0 is a suitable drug. choose

Method used

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  • Compound hypotensive tablet and preparation method thereof
  • Compound hypotensive tablet and preparation method thereof
  • Compound hypotensive tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0158] Example 1: Preparation of pharmaceutical composition in tablet form

[0159] prescription:

[0160] 0.1 parts by weight of reserpine,

[0161] Hydrochlorothiazide 12.5 parts by weight,

[0162] Triamterene 12.5 parts by weight,

[0163] Dihydralazine sulfate 12.5 parts by weight,

[0164] 30 parts by weight of sugar (sucrose and lactose are used in combination, the weight ratio of the two is 1:2),

[0165] 40 parts by weight of starch (pregelatinized starch and starch are used in combination, the weight ratio of the two is 1:2),

[0166] 1 part by weight of magnesium stearate.

[0167] Preparation method:

[0168] (1) each solid material is crushed into a fine powder that can pass through 120 mesh;

[0169] (2) Add hydrochlorothiazide, triamterene, carbohydrates and starches to the mixing granulator and mix evenly;

[0170] (3) Add reserpine and dihydralazine sulfate to 2.5 times the weight of purified water, fully stir until the powder is evenly dispersed, and ...

Embodiment 2

[0177] Embodiment 2: Preparation of pharmaceutical composition in tablet form

[0178] prescription:

[0179] 0.1 parts by weight of reserpine,

[0180] Hydrochlorothiazide 11 parts by weight,

[0181] Triamterene 14 parts by weight,

[0182] Dihydralazine sulfate 11 parts by weight,

[0183] 20 parts by weight of sugar (sucrose and lactose are used in combination, the weight ratio of the two is 1:1),

[0184] 50 parts by weight of starch (pregelatinized starch and starch are used in combination, the weight ratio of the two is 1:2.5),

[0185] 0.75 parts by weight of magnesium stearate.

[0186] Preparation method:

[0187] (1) each solid material is crushed into a fine powder that can pass through 120 mesh;

[0188] (2) Add hydrochlorothiazide, triamterene, carbohydrates and starches to the mixing granulator and mix evenly;

[0189] (3) Add reserpine and dihydralazine sulfate to 2 times the weight of purified water, fully stir until the powder is evenly dispersed, and...

Embodiment 3

[0196] Embodiment 3: Preparation of pharmaceutical composition in tablet form

[0197] prescription:

[0198] 0.1 parts by weight of reserpine,

[0199] Hydrochlorothiazide 14 parts by weight,

[0200] Triamterene 11 parts by weight,

[0201] Dihydralazine sulfate 14 parts by weight,

[0202] 40 parts by weight of sugar (sucrose and lactose are used in combination, the weight ratio of the two is 1:2.5),

[0203] 30 parts by weight of starch (pregelatinized starch and starch are used in combination, the weight ratio of the two is 1:1),

[0204] 1.25 parts by weight of magnesium stearate.

[0205] Preparation method:

[0206] (1) each solid material is crushed into a fine powder that can pass through 120 mesh;

[0207] (2) Add hydrochlorothiazide, triamterene, carbohydrates and starches to the mixing granulator and mix evenly;

[0208] (3) Add reserpine and dihydralazine sulfate to 3 times the weight of purified water, fully stir until the powder is evenly dispersed, and...

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Abstract

The invention relates to a compound hypotensive tablet and a preparation method thereof. Particularly, the invention relates to a pharmaceutical composition. The pharmaceutical composition comprises the following raw materials in parts by weight: 0.1 part of reserpine, 10-15 parts of hydrochlorothiazide, 10-15 parts of triamterene and 10-15 parts of dihydralazine sulfate. The invention further relates to a method for preparing the pharmaceutical composition. Furthermore, the invention further relates to a method for stabilizing the pharmaceutical composition in a tablet form. The method comprises a step of adding saccharides and starch additives to the pharmaceutical composition. The pharmaceutical composition comprises the reserpine, the hydrochlorothiazide, the triamterene and the dihydralazine sulfate. The compound hypotensive tablet is generally called Beijing hypotensive No.0 or No.0 in the field, is an excellent hypotensive drug which is accurate in curative effect, low in bad reaction and low in price, and has excellent pharmaceutical properties.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a kind of antihypertensive drug with excellent biological properties, in particular to a compound antihypertensive drug composition with excellent biological properties, more particularly to a kind of antihypertensive drug with excellent biological properties Antihypertensive drug composition comprising reserpine, triamterene and the like. The invention also relates to a process for the preparation of the composition. Background technique [0002] Since the 1980s, as a compound antihypertensive drug with definite curative effect, low side effects and low price, compound reserpine and triamterene tablets (used name: Beijing Jiangya No. 0, trademark: No. 0), It has been used clinically for more than 30 years, and it is still a star product of antihypertensive drugs. [0003] Compound Reserpine and Triamterene Tablets have been included in the second supplement of the 2010 edition ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61K9/20A61K9/36A61K47/26A61K47/36A61P9/12A61K31/475A61K31/502A61K31/519
Inventor 葛智勇吴涛赵海英王宝玲乔丽川
Owner CHINA RESOURCES DOUBLE CRANE PHARMA COMPANY
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