A kind of oligomeric guluronic acid phosphate and its preparation method and application

A technology of guluronic acid phosphate and polyguluronic acid, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problem of high industrialization cost, achieve low production cost, Significant immune enhancement, the effect of enhancing humoral immunity and cellular immunity
CN104650253BActive Publication Date: 2018-09-18OCEAN UNIV OF CHINA
4 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Patents(China)
Current Assignee / Owner
OCEAN UNIV OF CHINA
Publication Date
2018-09-18

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses an oligomeric guluronic acid phosphate as well as a preparation method and an application thereof. The molecular framework of oligomeric guluronic acid phosphate is a linear polymer of L-guluronic acid connected through alpha-(1,4)-glucosidic bonds, in the formula, R1 is pharmaceutical salt such as H, Li, Na, K, Ca or Mg, R2 is H or PO3<2->, the salting mode of -PO32- is accordant with that when R1 is taken as a substituent group, and n is less than or equal to 20. By adopting the oligomeric guluronic acid phosphate, the situation of low immunity of mice caused by cyclophosphamide can be alleviated, the major performance includes that the immune viscera / weight ratio can be increased, the humoral immunity and the cell immunity can be improved, the phagocytic ability of monocyte macrophages is improved, and the numbers of leukocytes and lymphocytes in peripheral hemogram can be remarkably increased. The pharmacology experiment result shows that the oligomeric guluronic acid phosphate disclosed by the invention can be used for preparing medicines, food or functional products with immunological enhancement.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of marine drugs and immune enhancers, and in particular relates to an oligomeric guluronic acid phosphate and its preparation method and application. Background technique

[0002] Polysaccharides are a class of natural biological response modifiers (Biological response modifiers, BRMs), which can enhance the body's specific and non-specific immune functions. For example, lentinan and astragalus polysaccharides are used as immune Enhancers are used in pharmaceuticals or functional products. However, most of the separation and purification processes of these polysaccharides are relatively cumbersome, and the industrialization cost is relatively high.

[0003] In recent years, polysaccharide phosphates, as a class of polysaccharide derivatives with special structures, have been reported to have biological activities such as immune regulation, anti-tumor, and anti-oxidation. In 1998, the Kitazawa group of Tohoku Univers...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More