Application of toremifene citrate in preparation of medicines for inhibiting tumor cell metastasis and diffusion

A technology of toremifene citrate and tumor cells, which is applied in the direction of antineoplastic drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as the undiscovered pharmacological effects of toremifene citrate, and achieve the reduction of research and development cycle, The effect of reducing the amount of death
CN104666284AInactive Publication Date: 2015-06-03NANJING ZHONG HONG HUA FEI INFORMATION TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING ZHONG HONG HUA FEI INFORMATION TECH CO LTD
Publication Date
2015-06-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an application of toremifene citrate in preparation of medicines for inhibiting tumor cell metastasis and diffusion. The metastasis ability of tumor cells is inhibited by the medicines prepared from the toremifene citrate, wherein the toremifene citrate is a low-toxicity medicine, and can play a relatively large blocking role in a tumor metastasis process; and meanwhile, treatment is carried out by virtue of other related tumor medicines, so that the mortality amount of normal cells can be greatly reduced; most of the existing tumor medicines are cytotoxic medicines; and a large number of normal cells die when the tumor cells are killed.
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Description

technical field

[0001] The invention relates to a new application of toremifene citrate in the field of pharmacy, in particular to the application of toremifene citrate in the preparation of drugs for inhibiting tumor cell metastasis and diffusion. Background technique

[0002] Toremifene citrate is a tamoxifen derivative. It can combine with estrogen receptors to produce estrogen-like effects, anti-hormone effects or both effects, which mainly depends on the length of treatment, animal species, sex and target organs.

[0003] Toremifene citrate tablets are indicated for postmenopausal women with estrogen receptor positive or unknown metastatic breast cancer.

[0004] Toremifene citrate competes with estrogen to bind to estrogen receptors in breast cancer cells, preventing estrogen-induced DNA synthesis and proliferation of cancer cells. High-dose toremifene citrate was used in some experimental tumors, showing that toremifene citrate has non-estrogen-dependent antitumor e...

Claims

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