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New application of paeoniflorin to treatment of esophageal achalasia

A technology of achalasia and paeoniflorin, which is applied in the drug field of paeoniflorin to treat achalasia, which can solve the problems of unclear etiology and lack of effective radical measures, and achieve the effects of definite curative effect, improved compliance and low price

Inactive Publication Date: 2015-06-24
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The etiology of the disease is unclear, and there is still no effective cure

Method used

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  • New application of paeoniflorin to treatment of esophageal achalasia
  • New application of paeoniflorin to treatment of esophageal achalasia
  • New application of paeoniflorin to treatment of esophageal achalasia

Examples

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example 1

[0030] 1. General Information

[0031] The inventor collected a total of 76 outpatients with esophageal achalasia from September 2013 to April 2014, aged 22-49 years, and the course of disease was 0.2-5 years. Randomly divided into: a treatment group of 50 cases, a blank group of 26 cases. There was no significant difference in age, condition and other data between the two groups, and they were comparable.

example 2

[0046] 1. General Information

[0047] The inventor also selected 55 outpatients in our hospital and randomly divided them into two groups. The treatment group consisted of 30 cases, 15 males and 15 females; aged 20 to 50 years, with an average of 32 years old. The control group consisted of 25 cases, including 15 males and 10 females; aged 20 to 40 years, with an average of 32 years old. Both groups had typical clinical manifestations and were diagnosed by swallowing time measurement and gastroscopy. There was no significant difference in general data between the two groups and were comparable.

[0048] 2. Treatment method

[0049]The control group was given Mosapride Tablets 5 mg, 3 times a day, orally before meals; Nifedipine 10 mg, orally 3 times a day. 4 weeks is a course of treatment. The treatment group was given the capsules prepared by the present invention, once in the morning and evening, 3 capsules / time, and 30 days was a course of treatment.

[0050] 3. Effi...

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Abstract

The invention discloses a medical new application of paeoniflorin, that is, an application of the paeoniflorin to esophageal achalasia. The purified paeoniflorin extracted from paeonia lactiflora has the obvious therapeutical effect on dysphagia, food regurgitation and chest pains of a patient suffering from the esophageal achalasia, and can improve concomitant symptoms of weight losing and the like of the patient. Common dosage forms, prepared by taking the paeoniflorin as main components, of capsules, tableting agents, granules and the like can be used for treating the esophageal achalasia. The dosage range for clinically curing the esophageal achalasia is 2 to 6mg / kg, and the optimal dosage is 4.3mg / kg. The application is definite in curative effect, small in toxic and side effects, low in cost and capable of improving the compliance of the patient suffering from the esophageal achalasia.

Description

Technical field [0001] The invention belongs to a medicine for treating achalasia of the cardia, in particular to a medicine for treating achalasia of the cardia by extracting paeoniflorin from Chinese herbal medicine peony. Background technique [0002] Achalasia is a common esophageal motility disorder. Primary achalasia is characterized by increased lower esophageal sphincter (LES) tension, loss of normal distal esophageal peristalsis, and LES relaxation disturbance during swallowing. The clinical manifestations are Dysphagia, regurgitation, and chest pain may be accompanied by weight loss and recurrent lung infections. The etiology of the disease is unclear, and there is still no effective cure. [0003] Esophageal achalasia is characterized by lack of peristalsis in the esophagus, high pressure in the lower esophageal sphincter, and abnormal relaxation during swallowing, which prevents food from entering the stomach smoothly. The initial manifestations are obstruction...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/00
Inventor 李纪鹏孙纪元陈文平李云龙贺奋飞李耀辉
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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