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A kind of preparation method of chitosan-based porous microsphere

A technology of porous microspheres and chitosan, which is applied in the preparation of microspheres, microcapsule preparations, chemical instruments and methods, etc., can solve the problems of increased environmental burden, consumption of raw materials, complicated processes, etc., to avoid biological toxicity and save raw materials. , the effect of simple process

Active Publication Date: 2017-01-25
福建梅生药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, the cross-linking agent has the disadvantage of biological toxicity. On the other hand, the addition of the cross-linking agent and porogen, the reaction between the cross-linking agent and the polymer, and subsequent washing and removal all require the consumption of raw materials, solvents and energy. The process is complicated, the cost is increased, and the environmental burden is aggravated

Method used

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  • A kind of preparation method of chitosan-based porous microsphere
  • A kind of preparation method of chitosan-based porous microsphere
  • A kind of preparation method of chitosan-based porous microsphere

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Experimental program
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Embodiment 1

[0039] The preparation method of embodiment 1 chitosan porous microspheres comprises the steps:

[0040] 1. Dissolve 1 g of chitosan in 100 mL of 1 wt % acetic acid aqueous solution, and remove foam.

[0041] 2. Dissolve 5g of Span 80 in 100mL petroleum ether solution.

[0042] 3. Take 10 mL of the chitosan solution obtained in step 1 as a dispersed phase and slowly add it to the continuous phase solution obtained in step 2, and stir at a high speed to obtain an emulsion.

[0043] 4. Place the emulsion in a freezer at -20°C for 4 hours to freeze and quench.

[0044] 5. Pour the mixed coagulation solution of 1wt% NaOH ethanol water at -20°C into the quenched emulsion and soak for 3 hours.

[0045] 6. Centrifuge to obtain chitosan microspheres, wash with ethanol and water for several times and then dry to obtain the product.

[0046] The chitosan microspheres that present embodiment prepares, its size and surface morphology are as follows figure 1 As shown, the size of the m...

Embodiment 2

[0047] The preparation method of embodiment 2 chitosan / PVA porous microspheres comprises the steps:

[0048] 1. Dissolve 0.5g chitosan and 0.5g PVA in 100mL of 1wt% acetic acid aqueous solution, and defoam.

[0049] 2. Dissolve 5g of Span 80 in 100mL petroleum ether solution.

[0050] 3. Take 10 mL of the mixed solution obtained in step 1 as the dispersed phase and slowly add it to the continuous phase solution obtained in step 2, and stir at high speed to obtain an emulsion.

[0051] 4. Place the emulsion in a freezer at -20°C for 4 hours to freeze and quench.

[0052] 5. Pour the mixed coagulation solution of 1wt% NaOH ethanol water at -20°C into the quenched emulsion and soak for 3 hours.

[0053] 6. Centrifuge to obtain chitosan / PVA composite microspheres, wash with ethanol and water respectively for several times, and then dry to obtain the product.

[0054] The chitosan / PVA composite microsphere that present embodiment prepares, its appearance is as follows image 3 ...

Embodiment 3

[0055] The preparation method of embodiment 3 chitosan / gelatin porous microspheres comprises the steps:

[0056] 1. Dissolve 0.5 g chitosan and 0.5 g gelatin in 100 mL of 1 wt % acetic acid aqueous solution, and defoam.

[0057] 2. Dissolve 5g of Span 80 in 100mL of toluene solution.

[0058] 3. Take 10 mL of the mixed solution obtained in step 1 as the dispersed phase and slowly add it to the continuous phase solution obtained in step 2, and stir homogeneously at a high speed to obtain an emulsion.

[0059] 4. Place the emulsion in a freezer at -20°C for 4 hours to freeze and quench.

[0060] 5. Pour the mixed coagulation solution of 1wt% NaOH ethanol water at -20°C into the quenched emulsion and soak for 3 hours.

[0061] 6. Centrifuge to obtain chitosan / gelatin composite microspheres, wash with ethanol and water for several times, and vacuum dry to obtain the product.

[0062] The chitosan / gelatin composite porous microsphere that present embodiment prepares, its morphol...

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Abstract

The invention relates to the field of high-molecular porous materials and particularly relates to a preparation method of porous chitosan-based microspheres for medicine carriers, adsorption and separation, hemostasis and wound dressing. The preparation method comprises the following steps: (a) respectively preparing solidification liquid, an emsulsifying-agent solution and a diluted-acid solution of pelletizing materials and precooling the solidification solution to minus 20 DEG C; (b) dripping the chitosan diluted-acid solution into the emsulsifying-agent solution, homogenizing and stirring to form emulsion; and (c) carrying out thermally-induced phase separation on the emulsion under the temperature ranging from minus 60 DEG C to minus 10 DEG C, adding precooled solidification liquid, carrying out reverse-phase regeneration and thus obtaining the chitosan-based porous microspheres. The preparation method has the beneficial effect that the surfaces and the inner parts of the porous microspheres have porous structures with communicated heights.

Description

technical field [0001] The invention relates to the field of polymer porous materials, in particular to a method for preparing porous chitosan-based microspheres that can be used for drug carriers, adsorption separation, hemostasis, and wound dressings. Background technique [0002] Polymer porous microspheres have the characteristics of rich pore structure and high specific surface area, making them widely used in drug carrier and controlled release, tissue engineering scaffold, catalyst carrier, metal ion and gas adsorption separation, hemostasis and other fields. For example, potato starch-based microporous polysaccharide microsphere hemostatic material has been commercialized by C.R. Bard Company (trade name: ARISTATMAH); chitosan porous microsphere loaded CuI catalyst (Chinese patent, CN102407162B); hydrophilic porous dextran Base microspheres are used for drug entrapment and release (Chinese patent, CN102258787B); metal ion imprinted chitosan porous microspheres are us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02B01J20/24B01J20/30C08J9/28C08J3/09C08L5/08C08L29/08C08L89/00C08L1/02C08L3/02
Inventor 刘海清李济祥覃王
Owner 福建梅生药业有限公司
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