Image preparation applied to early rapid detection of Alzheimer's disease and multi-mode imaging of early rapid detection

A multimodal imaging technology for senile dementia, applied in MRI/MRI contrast agents, echo/ultrasound imaging agents, preparations for in vivo tests, etc., can solve the problem of poor sensitivity and specificity of SPECT, Can not achieve early diagnosis, lack of specificity and other problems, achieve the effect of simple and easy detection method, no biological toxic side effects, and avoid biological toxicity

Active Publication Date: 2015-06-10
SOUTHEAST UNIV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing imaging methods commonly used to diagnose AD mainly include MRI (magnetic resonance imaging), SPECT (single photon emission tomography), PET (positron emission tomography), but these methods have certain limitations, such as: Although MRI provides morphological and certain functional basis for the diagnosis of AD, it lacks specificity; SPECT is not strong in sensitivity and specificity, and cannot achieve the purpose of early diagnosis of AD, while PET is expensive and limited. its application
So far, there are no reports on reagents capable of early, rapid, and multimodal imaging of AD-type Alzheimer's disease

Method used

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  • Image preparation applied to early rapid detection of Alzheimer's disease and multi-mode imaging of early rapid detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] First prepare transition metal ions, noble metal ions and their nano-clusters and porphyrin reagents with excellent biocompatibility, the specific steps are:

[0028] 1) Dissolve relevant transition metal ions, noble metal ions and their nano-clusters and porphyrin reagents in ultrapure water respectively, and prepare them to a certain concentration.

[0029] 2) Characterize the fluorescence emission and ultraviolet absorption spectra of related transition metal ions, noble metal ions and their nanoclusters, and porphyrin reagents with fluorescence spectrometers and ultraviolet spectrophotometers. Electrochemical and fluorescence studies on the interaction between reagents such as transition metal ions, noble metal ions and their nanoclusters and porphyrin derivatives with excellent biocompatibility, and targeting molecules such as A? protein and other protein molecules and related biological active substances and ultraviolet absorption spectroscopy to obtain the basis ...

Embodiment 2

[0033] In vivo imaging analysis of Alzheimer's disease model mice: Metal ions and their nanoclusters and porphyrin reagents used in the early, rapid, and multimodal detection of Alzheimer's disease. Cluster reagents and porphyrins are injected into normal control model mice and Alzheimer's model mice through tail vein injection or local injection. Metal ions and their nano-clusters and porphyrin reagents can be rapidly enriched in the lesion of the brain, using small animal living fluorescence The imager images the model mouse; the specific steps are:

[0034] (1) Constructing Alzheimer's disease model mice;

[0035] (2) Inject 0.3 mL sterile transition metal ions with a concentration of 10 mmol / L, noble metal ions and their nanoclusters and porphyrin reagent solutions at a concentration of 10 mmol / L, into normal control model mice and Alzheimer's model mice After 1-72 hours of non-invasive real-time dynamic high-sensitivity rapid tracing and monitoring, observe the internal ...

Embodiment 3

[0040] Same as Example 2, except that 0.1 mL of sterile transition metal ions and 100 mmol / L noble metal ions were used. The transition metal ion is cerium ion, the noble metal ion is platinum ion; the nano-cluster is silver nano-cluster; the porphyrin is tetra-p-sulfonic acid-phenyl porphyrin (TSPP). The result is the same as in Example 2.

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Abstract

The invention discloses a reagent for early rapid detection of Alzheimer's disease and an image preparation for multi-mode imaging of the early rapid detection. The reagent consists of transition metal ions and noble metal ions which have excellent biocompatibility, and nano-clusters and porphyrin derivatives of the transition metal ions and noble metal ions. An imaging detection reagent which can be used for accurately targeting and rapidly marking relative focus positions can be synthesized in fixed points by virtue of in-situ biological action, so that highly-sensitive and rapid tracing and monitoring with non-invasive, real-time and dynamic modes can be achieved; and moreover, the reagent cannot cause biologically toxic or side effects, and is simple, convenient and feasible in detection method. By adopting the medicines disclosed by the invention, the early, rapid and multi-mode (such as CT, ultrasound, fluorescence and MRI) imaging detection of the Alzheimer's disease can be achieved; and the medicines have wide medical application prospects.

Description

technical field [0001] The invention relates to a new type of imaging preparation applied to the early and rapid detection of Alzheimer's disease and its multimodal imaging. These reagents are composed of transition metal ions, noble metal ions and their nano-clusters and porphyrin derivatives with excellent biocompatibility. In situ bioaction fixed-point synthesis of imaging detection reagents that accurately target and quickly label relevant lesions can achieve non-invasive, real-time dynamic, high-sensitivity and rapid tracking and monitoring, without biological toxicity and side effects, and the detection method is simple and easy. Background technique [0002] Senile dementia is a degenerative disease of the central nervous system characterized by cognitive and visual-spatial disturbances. It has become one of the major diseases that threaten the health of the elderly, and its harm has surpassed heart disease, stroke, diabetes and cancer. At present, with the accelerati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K49/04A61K49/22A61K49/06
Inventor 王雪梅赵春秋来兰梅苏美娜李晓琦叶静陈传胜姜晖
Owner SOUTHEAST UNIV
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