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A new method for classification of liver samples and diagnosis of focal nodule dysplasia, hepatocellular adenoma, and hepatocellular carcinoma

A liver cell and sample technology, applied in the field of liver disease, its classification and diagnosis, can solve the problems of liver samples that have not been publicly classified

Inactive Publication Date: 2015-07-01
INTEGRAGEN +2
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  • Application Information

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Problems solved by technology

[0012] However, no method is disclosed in the prior art that really allows simple and reliable classification of liver samples in various types of liver diseases, as well as simple and reliable diagnosis of the presence of non-hepatic tissue in the liver, malignant hepatocellular carcinoma (HCC), benign Methods for focal nodular hyperplasia (FNH), hepatocellular adenoma and its subtypes

Method used

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  • A new method for classification of liver samples and diagnosis of focal nodule dysplasia, hepatocellular adenoma, and hepatocellular carcinoma
  • A new method for classification of liver samples and diagnosis of focal nodule dysplasia, hepatocellular adenoma, and hepatocellular carcinoma
  • A new method for classification of liver samples and diagnosis of focal nodule dysplasia, hepatocellular adenoma, and hepatocellular carcinoma

Examples

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Embodiment 1

[0265] Example 1. Identification of Molecular Signatures of Liver Samples Allowing Classification of Various Types of Liver Diseases

[0266] patients and methods

[0267] Patient and Tissue Samples

[0268] Liver samples were systematically frozen after resection of tumors from the liver at two French university hospitals in Bordeaux (from 1998 to 2007) and Créteil (from 2003 to 2007). A total of 550 samples were included in this work, and the study was approved by the local IRB committees (CCPRB Paris Saint-Louis, 1997 and 2004), and all patients signed their informed consent forms according to French law. The following were excluded: (1) tumors with >80% necrosis, (2) tumors with poor or insufficient RNA quality, (3) non-curatively resected HCC: R1 or R2 resection or extrahepatic metastases at the time of surgery, ( 4) HCC treated by liver transplantation.

[0269] Thus, the following samples are included:

[0270] 40 non-hepatocellular tumors, including intrahepatic ch...

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Abstract

The present invention relates to the technical field of liver diseases, their classification and diagnosis. It provides a new method for classifying a liver sample between non- hepatocellular sample; hepatocellular carcinoma (HCC) sample with further classification into one of subgroups G1 to G6; focal nodule dysplasia (FNH) sample; hepatocellular adenoma (HCA) sample with further classification into HNF1A mutated HCA, inflammatory HCA, β catenin mutated HCA or other HCA sample; and other benign liver sample, based on determination in vitro of genes expression profiles and analysis of the expression profile using algorithms calibrated with reference samples. The invention also provides kits for the classification of liver samples, and methods of treatment of liver disease in a subject based on a preliminary classification of a liver sample of said subject.

Description

technical field [0001] The present invention relates to the technical field of liver diseases, their classification and diagnosis. The present invention provides a new method for classifying liver samples among non-hepatocyte samples using an algorithm calibrated with reference samples, based on the determination of in vitro gene expression profiles and analysis of expression profiles; further classification into subgroup G1 Hepatocellular carcinoma (HCC) samples to one of G6; focal nodular dysplasia (FNH) samples; liver samples further classified as HNF1A-mutated HCA, inflammatory HCA, β-catenin-mutated HCA, or other HCA samples cellular adenoma (HCA) samples; and other benign liver samples. The present invention also provides kits for classifying a liver sample, and methods of treating liver disease in a subject based on the preliminary classification of the liver sample in said subject. Background technique [0002] Hepatocellular carcinoma (HCC) represents one of the l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68G16B25/10
CPCC12Q1/6886C12Q2600/158C12Q2600/112G16B25/00G16B25/10G16H50/20A61P1/16A61P35/00A61P43/00C12Q2600/16
Inventor A·德雷尼斯P·洛朗-普伊赫J·楚克曼-罗西J-C·诺
Owner INTEGRAGEN
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