Sevelamer carbonate dry suspension agent and preparation method thereof

Abstract

The invention provides a sevelamer carbonate dry suspension agent and a preparation method thereof. The sevelamer carbonate dry suspension agent comprises the followings: 40 to 90 parts of sevelamer carbonate, 500 to 2000 parts of a filling agent, 50 to 180 parts of a corrigent, 40 to 100 parts of a suspending agent, and 10 to 40 parts of a flocculating agent. The sevelamer carbonate dry suspension agent provided by the invention is uniform in distribution, excellent in stability, has a large distribution area in the stomach and intestine, is quickly absorbed, and high in bioavailability, takes effects quickly, and has a drug effect superior to that of a sevelamer carbonate premixing agent.

Description

technical field [0001] The invention relates to a dry suspension, in particular to a sevelamer carbonate dry suspension and a preparation method thereof. Background technique [0002] Dry suspensions refer to insoluble drugs and suitable excipients made into powders or granules, which can be dispersed into suspensions for oral administration by adding water and shaking before use. The dry suspension belongs to the suspension. After adding water to disperse, it should meet the quality requirements of the suspension. The particles in the suspension should be uniformly dispersed and should not be weighed quickly. It should be quickly redispersed. In addition to being effective and chemically stable, an ideal suspension should also (1) settle slowly and be able to redisperse by shaking gently after settling; (2) the size of the suspended particles should remain unchanged during long-term storage (3) Easy to dump. The above is the physical stability of the suspension. Dry sus...

AI Technical Summary

Problems solved by technology

[0005] In order to solve the shortcomings of poor water solubility and low bioavailability of existing Sevelamer Carbonate, the present invention invented Sevelamer Carbonate Dry Suspension

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