Sevelamer carbonate dry suspension agent and preparation method thereof
The technology of sevelamer carbonate and dry suspension is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., and can solve the problem of low bioavailability, sevelamer carbonate Problems such as poor water solubility, to achieve the effects of high bioavailability, fast onset of drug effect, and fast absorption
Inactive Publication Date: 2015-07-29
CP PHARMA QINGDAO CO LTD
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Problems solved by technology
[0005] In order to solve the shortcomings of poor water solubility and low bioavailability of existing Sevelamer Carbonate, the present invention invented Sevelamer Carbonate Dry Suspension
Method used
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Embodiment 1
[0030] Sevelamer Carbonate 50g
[0031] Mannitol 700g
[0032] Aspartame 50g
[0033] Methylcellulose: Dextran (2:1) 50g
[0034] Anhydrous disodium hydrogen phosphate 10g
Embodiment 2
[0036] Sevelamer Carbonate 50g
[0037] Mannitol 700g
[0038] Aspartame 50g
[0039] Methylcellulose: Dextran (1:1) 50g
[0040] Anhydrous disodium hydrogen phosphate 10g
Embodiment 3
[0042] Sevelamer Carbonate 50g
[0043] Mannitol 700g
[0044] Aspartame 50g
[0045] Methylcellulose: Dextran (3:1) 50g
[0046] Anhydrous disodium hydrogen phosphate 10g
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The invention provides a sevelamer carbonate dry suspension agent and a preparation method thereof. The sevelamer carbonate dry suspension agent comprises the followings: 40 to 90 parts of sevelamer carbonate, 500 to 2000 parts of a filling agent, 50 to 180 parts of a corrigent, 40 to 100 parts of a suspending agent, and 10 to 40 parts of a flocculating agent. The sevelamer carbonate dry suspension agent provided by the invention is uniform in distribution, excellent in stability, has a large distribution area in the stomach and intestine, is quickly absorbed, and high in bioavailability, takes effects quickly, and has a drug effect superior to that of a sevelamer carbonate premixing agent.
Description
technical field [0001] The invention relates to a dry suspension, in particular to a sevelamer carbonate dry suspension and a preparation method thereof. Background technique [0002] Dry suspensions refer to insoluble drugs and suitable excipients made into powders or granules, which can be dispersed into suspensions for oral administration by adding water and shaking before use. The dry suspension belongs to the suspension. After adding water to disperse, it should meet the quality requirements of the suspension. The particles in the suspension should be uniformly dispersed and should not be weighed quickly. It should be quickly redispersed. In addition to being effective and chemically stable, an ideal suspension should also (1) settle slowly and be able to redisperse by shaking gently after settling; (2) the size of the suspended particles should remain unchanged during long-term storage (3) Easy to dump. The above is the physical stability of the suspension. Dry sus...
Claims
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IPC IPC(8): A61K9/14A61K31/785A61K47/38A61K47/36A61P3/12A61P7/08
Inventor 王明刚陈阳生任莉刘晓霞翟翠云孙桂玉
Owner CP PHARMA QINGDAO CO LTD
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