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Extraction method and application of anti-tumor traditional Chinese medicine extract

An extraction method and extraction technology, which are applied in the field of anti-tumor traditional Chinese medicine extracts and their extraction, can solve the problems of high cost and large body damage, and achieve the effects of low cost, reduced expression, and improved promotion

Active Publication Date: 2017-11-07
SHAANXI UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And traditional tumor (malignant tumor) treatment adopts means such as western medicine, radiotherapy, chemotherapy or operation more, and expense is expensive, and damage to body is very big; It is a technical problem that people need to solve urgently

Method used

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  • Extraction method and application of anti-tumor traditional Chinese medicine extract
  • Extraction method and application of anti-tumor traditional Chinese medicine extract
  • Extraction method and application of anti-tumor traditional Chinese medicine extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Using the dried rhizome of Hylomecon japonica (Thunb.) pratl as raw material, reflux extraction with ethanol with a volume concentration of 70% and a mass 20 times that of the raw material, to obtain the first extract and the first extracted medicinal residue; Adding ethanol with a volume concentration of 70% and a mass 18 times that of the raw material to the first extracted dregs is used for secondary extraction to obtain a second extract and a second extracted dregs; in the second extracted dregs Adding ethanol with a volume concentration of 70% and a quality 18 times that of the raw material is extracted for the third time to obtain a third extract and a third extract of medicinal residues; the first extract, the second extract, and The third extracts are combined to obtain an extract; the extracts are concentrated to obtain a thick ointment; the thick ointment is dried at 70° C. and then pulverized to obtain an anti-tumor traditional Chinese medicine extract.

Embodiment 2

[0060] Using the dried rhizome of H.japonica (Thunb.) pratl.Var.dissecta (Franch savat.) Fedde as raw material, reflux extraction with ethanol with a volume concentration of 60% and a mass 19 times that of the raw material, to obtain The first extraction liquid and the first extraction dregs; adding ethanol with a volume concentration of 60% and a mass 17 times that of the raw material in the first extraction dregs for secondary extraction to obtain the second extraction liquid and the second extraction dregs. Extracting medicinal residues; adding ethanol with a volume concentration of 70% and a mass 17 times that of the raw material to the second extracted medicinal residues for a third extraction to obtain a third extract and a third extracted medicinal residues; The first extract, the second extract and the third extract are combined to obtain an extract; the extract is concentrated to obtain a thick paste; the thick paste is dried at 65°C and crushed to obtain Antitumor tr...

Embodiment 3

[0062] With the dry rhizome of H.japonica (Thunb.) pratl.Var.Subincia Fedde as raw material, the volume concentration is 80%, and the quality is 21 times of the ethanol reflux extraction of the raw material to obtain the first extract and The first extraction of medicinal residues; adding ethanol with a volume concentration of 80% and a mass 19 times that of the raw material to the first extraction medicinal residues for secondary extraction to obtain a second extraction liquid and second extraction medicinal residues; Adding ethanol with a volume concentration of 80% and a mass 18 times that of the raw material to the second extracted dregs is added for a third extraction to obtain a third extract and a third extracted dregs; the first extract , the second extract and the third extract are combined to obtain an extract; the extract is concentrated to obtain a thick paste; the thick paste is dried at 70°C and crushed to obtain an anti-tumor traditional Chinese medicine extract ...

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Abstract

The invention provides an extraction method and application of an anti-tumor traditional Chinese medicine extract, belonging to the field of traditional Chinese medicine. The extraction method of the anti-tumor traditional Chinese medicine extract comprises the steps of using the rhizomes of Papaveraceae and Nelumbo plants as raw materials, carrying out ethanol reflux extraction, and concentrating and drying the obtained extract to obtain the anti-tumor traditional Chinese medicine extract. The anti-tumor traditional Chinese medicine extract can increase the percentage of cells in the G1 phase of HT-29 and SW620 cells, and can reduce the ratio of cells in the S phase and G2 phase of the tumor cells, and can induce the G1 phase arrest of HT-29 and SW620 cells, and The effect of inhibiting the proliferation ability of these two tumor cells; in addition, after the anti-tumor Chinese medicine extract treats colon cancer cells, it will increase the expression of activated forms of caspase-3 and caspase-9, and will increase the expression of pro-apoptotic proteins and reduce the expression of apoptosis-inhibiting proteins.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to an anti-tumor traditional Chinese medicine extract and its extraction method and application. Background technique [0002] my country has a vast territory, diverse natural conditions, and extremely rich traditional medicine resources. It is the country with the most types of natural medicine resources and the longest cultivation history in the world. And many authentic medicinal materials are well-known at home and abroad, and exported to more than 100 countries and regions. [0003] Chinese herbal medicine has unique advantages that are incomparable to western medicine, such as natural materials, stable effects, and less toxic and side effects. With the progress of society and the development of productivity, people are increasingly pursuing health and longevity. Modern people are increasingly turning their attention from synthetic medicine to natural medicine. It i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P35/00
Inventor 孙静张欣孙阳唐志书郭东艳
Owner SHAANXI UNIV OF CHINESE MEDICINE
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