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A kind of method for preparing pyruvic acid

A technology of pyruvic acid and catalyst, applied in the field of preparation of pyruvic acid, can solve the problems of loss and loss of catalyst potassium hydrogen sulfate, hindering commercial application, not conforming to environmental protection, etc., and achieves the effects of easy separation, cost reduction, and high selectivity

Active Publication Date: 2017-03-01
QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The potassium hydrogen sulfate used in this method is constantly consumed in the dehydration and decarboxylation process of tartaric acid, and is discharged into the atmosphere in the form of gas pollutant SOx, causing environmental pollution and does not meet the requirements of environmental protection, while the catalyst potassium hydrogen sulfate is also constantly being consumed loss
Due to the wide application of pyruvate in drug synthesis, daily chemical industry and food industry, the commercial demand of pyruvate continues to expand. However, potassium bisulfate catalyzed tartaric acid method will produce SOx, which will pollute the environment and hinder its commercial application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Molybdenum vanadium niobium composite metal oxide Mo 0.61 V 0.31 Nb 0.08 o 2.81 Preparation: 7.2g oxalic acid (C 2 h 2 o 4 2H 2 O), 3.63g ammonium metavanadate (NH 4 VO 3 ) was dissolved in 25ml ultrapure water, 10.77g ammonium paramolybdate ((NH 4 ) 6 Mo 7 o 24 4H 2 O) Dissolve in 25ml of ultrapure water, mix the above two completely dissolved solutions at a temperature of 40-60°C, and take 2.42g of ammonium niobate oxalate hydrate (C 4 h 4 NbO 9 ·xH 2 O) Dissolve in 25ml of ultra-pure water, then add the solution dropwise into the mixed solution containing molybdenum and vanadium, and stir under vacuum at 90°C until the solvent is almost completely volatilized to obtain a semi-solid catalyst. Dry overnight at 120°C, and then roast the dried catalyst at 400°C in a sufficient air atmosphere for about 4 hours to obtain the catalyst Mo 0.61 V 0.31 Nb 0.08 o 2.81 .

[0026] Tartaric acid is prepared pyruvic acid: in reactor, add 5g tartaric acid, 60ml ...

Embodiment 2

[0030] Molybdenum vanadium niobium composite metal oxide Mo 0.61 V 0.31 Nb 0.08 o 2.81 Preparation: 7.2g oxalic acid (C 2 h 2 o 4 2H 2 O), 3.63g ammonium metavanadate (NH 4 VO 3 ) was dissolved in 25ml ultrapure water, 10.77g ammonium paramolybdate ((NH 4 ) 6 Mo 7 o 24 4H 2 O) Dissolve in 25ml of ultrapure water, mix the above two completely dissolved solutions at a temperature of 40-60°C, and take 2.42g of ammonium niobate oxalate hydrate (C 4 h 4 NbO 9 ·xH 2 O) be dissolved in 25ml ultrapure water, then add the solution dropwise to the mixed solution containing molybdenum and vanadium, stir under vacuum at 90°C until the solvent is almost completely volatilized to obtain a semi-solid catalyst, place the catalyst Dry overnight at a temperature of 120°C, and then roast the dried catalyst at a temperature of 400°C in a sufficient air atmosphere for about 4 hours to obtain the catalyst Mo 0.61 V 0.31 Nb 0.08 o 2.81 .

[0031] Tartaric acid is prepared pyruvi...

Embodiment 3

[0035] Preparation of pyruvic acid from tartaric acid: Add 5g tartaric acid and 60ml heat transfer oil into the reactor, stir the two evenly and then slowly raise the temperature to 200°C, then pass in air, the air flow rate is 80ml / min, and the reaction is under low negative pressure (about -0.08MPa ), and a certain liquid product was obtained after 1 hour of reaction. After analysis by gas chromatography-mass spectrometry (GC-MS), the product mixture contained a small amount of acetaldehyde, acetic acid, etc., and almost no pyruvic acid was detected.

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PUM

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Abstract

The present invention relates to a pyruvic acid preparation method, specifically to a method for using a molybdenum-vanadium-niobium composite metal oxide catalyst to efficiently catalyze tartaric acid to generate pyruvic acid. According to the method, a molybdenum-vanadium-niobium composite metal oxide is adopted as a catalyst, reacting is performed at a temperature of 160-210 DEG C under an oxidizing atmosphere under a negative pressure condition in the presence of a high boiling solvent, and a raw material tartaric acid is subjected to dewatering decarboxylation through catalysis to generate the pyruvic acid, wherein the reaction time is 0.5-3 h, and the catalyst use amount accounts for 5-50% of the use amount of the raw materials. According to the present invention, the catalyst is the heterogeneous catalyst, the catalyst activity is high, the product is easily separated from the catalyst, the catalyst can be recycled, the reaction temperature is low, the process operation is simple, and the catalyst provides high selectivity for pyruvic acid.

Description

[0001] field of invention [0002] The invention is a preparation method of pyruvic acid, specifically a method for efficiently catalyzing tartaric acid to generate pyruvic acid using a molybdenum vanadium niobium composite metal oxide catalyst. Background technique [0003] Pyruvate is the smallest molecule with two functional groups, carbonyl and carboxyl, and is often used as an intermediate in drug synthesis and organic synthesis. In terms of medicine and health care, it can be used to synthesize drugs for the treatment of high blood pressure, antiviral agents, sedatives, etc. Calcium pyruvate, a derivative of pyruvate, is the main component of high-efficiency weight-loss health care drugs currently on the market; it is used in agriculture. Used in the synthesis of fungicides and herbicides; in daily chemical industry, it can be used as whitening agent, preservative, antioxidant and preservative. In addition, pyruvate is the simplest molecular structure among α-keto acids...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C59/19C07C51/38C07C51/373B01J23/28
CPCY02P20/584
Inventor 李学兵李红宋亮苗诗轩
Owner QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI