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Pharmacological active substance extracted from natural plants and application thereof

A technology of active substances and natural plants, applied in plant raw materials, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc., to achieve the effect of inhibiting tumor growth, prolonging survival time, and prolonging survival time

Inactive Publication Date: 2015-08-05
JIYANG COLLEGE OF ZHEJIANG A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a natural plant, there has never been any report on the anti-tumor activity of the hanging grass

Method used

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  • Pharmacological active substance extracted from natural plants and application thereof
  • Pharmacological active substance extracted from natural plants and application thereof
  • Pharmacological active substance extracted from natural plants and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Grinding and extraction of raw materials: Dried the hanging grass and chopped it properly, put it in the container of the crushing extractor, and carried out crushing and extraction twice with 70% aqueous ethanol equivalent to 8 times the dry weight of the hanging grass. 2 minutes each time. (2) Flash concentration and decolorization: The obtained extract is suction-filtered or shake-filtered, and the filter residue is discarded, and the extract is flash-concentrated to half of the original volume by using a vacuum thin-film concentration device below 70°C. Add powdered activated carbon equivalent to 2% of the dry weight of medicinal materials, ultrasonically treat at room temperature for 1 hour, filter with suction to remove activated carbon, and continue to flash and concentrate to 1 / 8 of the original volume at a temperature below 70°C using a vacuum thin film concentration device. (3) Preparation of ether extract: ultrasonically disperse the concentrated solution...

Embodiment 2

[0027](1) Grinding and extraction of raw materials: Dried the hanging grass and chopped appropriately, put it in the container of the crushing extractor, and crushed and extracted once with 60% aqueous ethanol equivalent to 7 times the dry weight of the hanging grass. 3 minutes each time. (2) Flash concentration and decolorization: The obtained extract is suction-filtered or shake-filtered, and the filter residue is discarded, and the extract is flash-concentrated to half of the original volume by using a vacuum thin-film concentration device below 70°C. Add powdered activated carbon equivalent to 1.5% of the dry weight of medicinal materials, ultrasonically treat for 1.5 hours at room temperature, filter with suction, remove the activated carbon, and continue to flash and concentrate to 1 / 7 of the original volume by using a vacuum thin film concentration device below 70°C. (3) Preparation of ether extract: ultrasonically disperse the concentrated solution into water, and the ...

Embodiment 3

[0029] (1) Grinding and extraction of raw materials: dry the stalk grass and chop it properly, put it in the container of the crushing extractor, and use 75% aqueous ethanol equivalent to 6 times the dry weight of the stalk grass to carry out crushing and extraction for 3 times, each time 1.5 minutes each time. (2) Flash concentration and decolorization: The obtained extract is suction-filtered or shake-filtered, and the filter residue is discarded, and the extract is flash-concentrated to half of the original volume by using a vacuum thin-film concentration device below 70°C. Add powdered activated carbon equivalent to 2.5% of the dry weight of the medicinal materials, ultrasonically treat for 0.5 hours at room temperature, filter with suction, remove the activated carbon, and continue to flash and concentrate to 1 / 6 of the original volume at a temperature below 70°C using a vacuum thin film concentration device. (3) Preparation of ether extract: ultrasonically disperse the c...

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Abstract

A pharmacological active substance extracted from natural plants and an application thereof. The invention belongs to the technical field of natural plant extraction. The pharmacological active substance is prepared through the following method including: 1) crushing and extracting raw materials, 2) flashing the extracted substance to concentrating the extracted substance and decoloring the extracted substance; 3) preparing an ethyl ether extract; 4) preparing an ethyl acetate extract; and 5) preparing a n-butyl alcohol extract; 6) mixing the ethyl acetate extract with the n-butyl alcohol extract according to the weight ratio of 1:1-3 to obtain the anti-tumor pharmacological active substance. According to the application of the pharmacological active substance extracted from the natural plants, the pharmacological active substance has a significant inhibiting effect on proliferation of human liver cancer cells and has a significant inhibiting effect on H22 mouse liver solid tumor and ascitic tumor, and especially, a high-dose group can significant inhibit growth of the tumor on H22 mouse and prolong survival time of the mouse, thereby providing time for treating liver tumor, prolonging survival time and improving life quality.

Description

technical field [0001] The invention belongs to the technical field of natural plant extraction, in particular to medicinal active substances extracted from natural plants and applications thereof. Background technique [0002] In recent years, the incidence of tumors has been increasing year by year, which seriously threatens human life and health. The research and development of anti-tumor drugs has also attracted great attention from governments. Tumor is an abnormal lesion formed by the body under the action of various carcinogenic factors when a certain cell in a local tissue loses its normal regulation of its growth at the gene level, resulting in its clonal abnormal proliferation. Tumors are generally divided into two categories, benign and malignant. Malignant tumors, as one of the largest public health problems in the world, have greatly endangered human health and will become the first killer of human beings in the new century. [0003] Lob grass Hyptis rhomboid...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P35/00
Inventor 袁珂蔡荣荣段芳芳
Owner JIYANG COLLEGE OF ZHEJIANG A & F UNIV