A pharmaceutical composition for preventing and treating cyclosporin A chronic nephrotoxicity

A composition, nephrotoxicity technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of difficulty, complex occurrence mechanism, retention, etc.

Active Publication Date: 2017-10-10
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, on the one hand, due to the complex mechanism of CsA nephrotoxicity, multiple pathways or targets are involved, it is difficult for a single component or a drug acting on a single target to effectively protect against its nephrotoxicity; on the other hand, because the current research is out of clinical practice , so that the above research only stays in the laboratory stage

Method used

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  • A pharmaceutical composition for preventing and treating cyclosporin A chronic nephrotoxicity
  • A pharmaceutical composition for preventing and treating cyclosporin A chronic nephrotoxicity
  • A pharmaceutical composition for preventing and treating cyclosporin A chronic nephrotoxicity

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0112] Example 1: (granules)

[0113] Prescription: 1200g of golden cherry, 1000g of emblica, 600g of schisandra, 1500g of gynostemma

[0114] Preparation method: Extract the raw material medicine with water for 3 times according to the above ratio, add 12 times of water to decoct for 1 hour each time, then combine the decoction liquid, filter, and finally concentrate the filtrate to an extract with a relative density of about 1.30, and then decoct it by weight Take a mixture of dextrin and mannitol that is twice the amount of the extract, the ratio of dextrin and mannitol is 1:1.5, mix the two thoroughly, then add a small amount of extract to make a soft material, and pass through a 24-mesh sieve Granulated, dried, whole, divided into packs of 15 grams.

[0115] Dosage: 15g each time, 2 times a day, take it with warm water.

example 2

[0116] Example 2: (granules)

[0117] Prescription: 1200g golden cherry, 900g emblica, 600g schisandra, 1600g gynostemma

[0118] Preparation method: Extract the raw material medicine with water for 3 times according to the above ratio, add 12 times of water to decoct for 1 hour each time, then combine the decoction liquid, filter, and finally concentrate the filtrate to an extract with a relative density of about 1.30, and then decoct it by weight Take a mixture of dextrin and mannitol that is twice the amount of the extract, the ratio of dextrin and mannitol is 1:1.5, mix the two thoroughly, then add a small amount of extract to make a soft material, and pass through a 24-mesh sieve Granulated, dried, whole, divided into packs of 15 grams.

[0119] Dosage: 15g each time, 2 times a day, take it with warm water.

example 3

[0120] Example 3: (granules)

[0121] Prescription: 1300g golden cherry, 900g emblica, 600g schisandra, 1500g gynostemma

[0122] Preparation method: Extract the raw material medicine with water for 3 times according to the above ratio, add 12 times of water to decoct for 1 hour each time, then combine the decoction liquid, filter, and finally concentrate the filtrate to an extract with a relative density of about 1.30, and then decoct it by weight Take a mixture of dextrin and mannitol that is twice the amount of the extract, the ratio of dextrin and mannitol is 1:1.5, mix the two thoroughly, then add a small amount of extract to make a soft material, and pass through a 24-mesh sieve Granulated, dried, whole, divided into packs of 15 grams.

[0123] Dosage: 15g each time, 2 times a day, take it with warm water.

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Abstract

The invention relates to a medical configuration item, and particularly relates to a chronic cyclosporin A nephrotoxicity prevention and treatment pharmaceutical composition, the pharmaceutical composition comprises an effective component and a pharmaceutical acceptable auxiliary material, the effective component is an aqueous extract prepared from the following medicinal raw materials by weight: 26-30% of fructus rosae laevigatae, 20-25% of emblic leafflower fruit, 12-15% of fruit of Chinese magnoliavine and 30-40% of gynostemma pentaphylla. The chronic cyclosporin A nephrotoxicity prevention and treatment pharmaceutical composition has remarkable effect on chronic cyclosporin A nephrotoxicity prevention and treatment.

Description

field of invention [0001] The invention relates to a medical preparation, in particular to a pharmaceutical composition using plants as raw materials. Background technique [0002] Cyclosporine A (CsA) is a calcineurin inhibitor (CNI). In 1980, the "CsA + azathioprine + corticosteroid" triple immunosuppressive regimen came out, making clinical kidney, heart, liver, and pancreas transplantation more effective. The 1-year survival rate increased from 50% to 80%, the 5-year survival rate increased from 25% to 60%, and the incidence of complications decreased significantly. Since then, the field of organ transplantation has officially entered the era of CsA. Statistics in 2005 showed that 94% of kidney transplants were performed. Patients were treated with a CNI-based immunosuppressive regimen after transplantation. At present, CsA is not only still the first-line drug against organ transplant rejection, but also has greatly expanded the application field as an excellent immuno...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/738A61P13/12
Inventor 于洋全世建黎同明张晨雪魏家保赖巧
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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