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A kind of potassium chloride sustained-release tablet and preparation method thereof

A potassium chloride sustained-release tablet and potassium chloride technology, applied in the direction of active ingredients of alkali/alkaline earth metal chlorides, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problem of uneven drug release, burst release or release Incomplete medicine and other problems, to achieve the effect of good fluidity, improved bioavailability, and high safety factor

Active Publication Date: 2017-12-01
SHENZHEN CHINA ASSOCD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Matrix-type sustained-release tablets have the problems of uneven drug release, sudden release or incomplete drug release

Method used

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  • A kind of potassium chloride sustained-release tablet and preparation method thereof
  • A kind of potassium chloride sustained-release tablet and preparation method thereof
  • A kind of potassium chloride sustained-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Preparation of Potassium Chloride Sustained-release Tablets

[0029] (1) Gastric-soluble sustained-release pellets

[0030]

[0031] (2) Enteric-coated sustained-release pellets

[0032]

[0033] (3) Sustained-release tablets

[0034]

[0035]

[0036] Preparation:

[0037] (1) Dissolve potassium chloride in 0.1mol / L hydrochloric acid solution, add mesoporous carbon and stir evenly, add acrylic resin IV and stir until completely dissolved, add Span 80 and stir until completely dissolved; add the mixed solution into liquid paraffin, Stir quickly until the emulsification is uniform; heat the prepared emulsion to 100°C under stirring, continue to stir to remove the hydrochloric acid solution, filter, wash the liquid paraffin with cyclohexane, and dry to obtain potassium chloride stomach-soluble sustained-release pellets .

[0038] (2) Dissolve potassium chloride in saturated ammonia water, add mesoporous carbon and stir evenly, add acrylic res...

Embodiment 2

[0040] Embodiment 2: Preparation of Potassium Chloride Sustained-release Tablets

[0041] (1) Gastric-soluble sustained-release pellets

[0042]

[0043] (2) Enteric-coated sustained-release pellets

[0044]

[0045] (3) Sustained-release tablets

[0046]

[0047]

[0048] Preparation:

[0049] (1) Dissolve potassium chloride in 0.1mol / L hydrochloric acid solution, add mesoporous carbon and stir evenly, add acrylic resin IV and stir until completely dissolved, add Span 80 and stir until completely dissolved; add the mixed solution into liquid paraffin, Stir quickly until the emulsification is uniform; heat the prepared emulsion to 100°C under stirring, continue to stir to remove the hydrochloric acid solution, filter, wash the liquid paraffin with cyclohexane, and dry to obtain potassium chloride stomach-soluble sustained-release pellets .

[0050] (2) Dissolve potassium chloride in saturated ammonia water, add mesoporous carbon and stir evenly, add acrylic resin...

Embodiment 3

[0052] Embodiment 3: Preparation of Potassium Chloride Sustained-release Tablets

[0053] (1) Gastric-soluble sustained-release pellets

[0054]

[0055] (2) Enteric-coated sustained-release pellets

[0056]

[0057]

[0058] (3) Sustained-release tablets

[0059]

[0060] Preparation:

[0061] (1) Dissolve potassium chloride in 0.1mol / L hydrochloric acid solution, add mesoporous carbon and stir evenly, add acrylic resin IV and stir until completely dissolved, add Span 80 and stir until completely dissolved; add the mixed solution into liquid paraffin, Stir quickly until the emulsification is uniform; heat the prepared emulsion to 100°C under stirring, continue to stir to remove the hydrochloric acid solution, filter, wash the liquid paraffin with cyclohexane, and dry to obtain potassium chloride stomach-soluble sustained-release pellets .

[0062] (2) Dissolve potassium chloride in saturated ammonia water, add mesoporous carbon and stir evenly, add acrylic res...

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Abstract

The invention discloses a potassium chloride sustained release tablet and a preparation method thereof. The potassium chloride sustained release tablet is formed by directly tabletting gastric-soluble sustained-release pellets, enteric-coated sustained-release pellets and other pharmaceutically acceptable auxiliary materials, wherein the gastric-soluble sustained-release pellets comprise potassium chloride, mesoporous carbon, acrylic resin IV and surfactant; the enteric-coated sustained-release pellets comprise potassium chloride, mesoporous carbon, acrylic resins I-III and surfactant. According to the invention, the potassium chloride sustained release tablet is smooth in drug release, good in drug release stability, and free from burst release.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a slow-release tablet containing potassium chloride and a preparation method thereof. Background technique [0002] Potassium chloride is a commonly used electrolyte balance regulating drug in clinical practice. It has definite clinical curative effect and is widely used in various clinical departments. It is used to treat and prevent hypokalemia caused by various reasons (insufficient food intake, vomiting, severe diarrhea, application of potassium-sparing diuretics or long-term application of glucocorticoid and adrenocortico-stimulating hormone, potassium-losing nephropathy, Bartter syndrome, etc.) It can also be used for frequent, multi-source premature beats or rapid arrhythmia caused by cardiac and renal edema and cardiac glycoside poisoning such as digitalis. [0003] Potassium chloride is known to be a gastrointestinal irritant, often causi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K33/14A61K47/32A61P33/12
Inventor 陈卫陈振华陆琴罗晓敏汪承英梁粤刘亚楠邹贤宝
Owner SHENZHEN CHINA ASSOCD PHARMA