Dispersible tablet for treating rhinitis and preparation method thereof

A technology for dispersible tablets and rhinitis, applied in the field of dispersible tablets for the treatment of rhinitis and its preparation, can solve the problems of poor patient compliance and low bioavailability, and achieve the effects of fast absorption, high bioavailability, and improved bioavailability

Active Publication Date: 2018-06-05
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The original commercially available products are mainly ordinary tablets and pills. For the elderly or patients with dysphagia, the original commercially available products have the disadvantages of poor patient compliance and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0015] The preparation method of the dispersible tablet for the treatment of rhinitis comprises the following steps:

[0016] (1) Weigh the patchouli leaves, cut them into pieces, add water to reflux and extract for 2-4 hours, and obtain the patchouli volatile oil; according to the patchouli volatile oil: β-cyclodextrin: water = 1: (5-10): (10-30) weight ratio, first add β-cyclodextrin with water and stir while heating until β-cyclodextrin is basically dissolved, slowly add patchouli volatile oil, stir until the color is uniform, cool, and precipitate β-cyclodextrin Refining, filtering, taking the filter residue, drying at low temperature, and pulverizing to obtain the β-cyclodextrin inclusion complex of patchouli volatile oil. Preferably, the β-cyclodextrin is heated to 50-90° C. while adding water while stirring.

[0017] (2) Sieve the patchouli volatile oil β-cyclodextrin inclusion compound, pig bile powder and the following auxiliary materials. The drug in the dispersibl...

Embodiment 1

[0024] (1) Take the patchouli leaves of the specified weight, cut them into pieces, place them in a round bottom flask, add an appropriate amount of water to reflux and extract for 2 hours, and obtain the patchouli volatile oil; according to the patchouli volatile oil: β-cyclodextrin: The ratio of water = 1:7:21, first add an appropriate amount of water to the cyclodextrin in the beaker, then place the beaker on a magnetic stirrer, and heat it to 80°C while stirring, so that the β-cyclodextrin is basically dissolved. Slowly add patchouli volatile oil, stir until the color is uniform, cool, precipitate β-cyclodextrin, filter, take the filter residue, dry at low temperature, and pulverize to obtain patchouli volatile oil β-cyclodextrin inclusion compound.

[0025] (2) Pass the patchouli volatile oil β-cyclodextrin inclusion compound, pig bile powder and various auxiliary materials through a 100-mesh sieve.

[0026] (3) according to the portion of preparing 1000 dispersible table...

Embodiment 2

[0028] (1) Take patchouli leaves of specified weight, cut them into pieces, put them in a round bottom flask, add appropriate amount of water to reflux and extract for 3 hours, and obtain patchouli volatile oil; according to patchouli volatile oil: β-cyclodextrin: The ratio of water = 1:9:15, first add appropriate amount of cyclodextrin to the beaker, then place the beaker on a magnetic stirrer, heat to 60°C while stirring, to basically dissolve the β-cyclodextrin, Slowly add patchouli volatile oil, stir until the color is uniform, cool, precipitate β-cyclodextrin, filter, take the filter residue, dry at low temperature, and pulverize to obtain patchouli volatile oil β-cyclodextrin inclusion compound.

[0029] (2) Pass the patchouli volatile oil β-cyclodextrin inclusion compound, pig bile powder and various auxiliary materials through a 100-mesh sieve.

[0030](3) according to the portion of preparing 1000 dispersible tablets, take by weighing the patchouli volatile oil β-cycl...

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Abstract

The invention discloses a dispersible tablet for treating rhinitis and a preparation method thereof. Fragrance volatile oil β-cyclodextrin inclusion compound, pig bile powder, calcium hydrogen phosphate, microcrystalline cellulose, crospovidone, sodium carboxymethyl starch, sucralose, sieve and mix well, add povidone solution Carry out soft materials, granulate and granulate, finally add magnesium stearate, carry out tabletting and obtain. The dispersible tablet and its molding process developed by the present invention can improve the bioavailability and patient compliance of traditional Huodan pills, and have the characteristics of convenient taking, rapid disintegration, fast absorption and high bioavailability, and are simple to prepare and convenient to take. It can reduce the adverse reactions of drugs, improve the bioavailability of drugs, etc., and is especially suitable for the elderly, young children and patients who have difficulty swallowing, and has a good development prospect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a dispersible tablet for treating rhinitis and a preparation method thereof. Background technique [0002] The main components of the medicine of the present invention are patchouli leaves and pig gall powder, which have the functions of aromatizing turbidity, clearing away heat and opening the orifice, and are mainly used for nasal congestion, runny or turbid nasal discharge, Forehead headache, good effect in treating rhinitis and sinusitis. The original commercially available products are mainly ordinary tablets and pills. For the elderly or patients with dysphagia, the original commercially available products have the disadvantages of poor patient compliance and low bioavailability. Contents of the invention [0003] The object of the present invention is to solve the problems of the original commercially available products. We provide a prepar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/32A61K47/36A61K36/532A61P11/02A61K35/413
Inventor 肖炜翁立冬洪军辉张璐
Owner SOUTHERN MEDICAL UNIVERSITY
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