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Synthesis method of magnesium L-threonate

A technology of magnesium threonate and a synthesis method, which is used in the separation/purification of carboxylic acid compounds, the preparation of carboxylic acids by oxidation, organic chemistry, etc. Effect

Active Publication Date: 2015-10-07
启东东岳药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Combined with the demand for higher bulk density of magnesium L-threonate in the current market, it is obvious that this method has many defects and is not suitable for product marketization

Method used

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  • Synthesis method of magnesium L-threonate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 40g (0.227mol) of vitamin C and add it to a 500mL three-neck flask, add 160mL of water, start stirring, slightly raise the temperature to 20-25°C, after the vitamin C is dissolved, cool down to 20-30°C, and slowly add heavy magnesium carbonate 30.5 g (0.305mol based on magnesium oxide (40%)), after adding, cool down to 18-25°C, add 63.66g (28%, 0.524mol) of hydrogen peroxide dropwise (control the temperature at 18-25°C), dropwise, 18- Incubate at 25°C for 2.5 hours. After the heat preservation is completed, heat up to 50-55°C for 1 hour. At this time, add 4.2g of medicinal charcoal, heat up to 70-75°C and continue to heat for 2 hours. After heat preservation, cool down to 25-30°C. Suction filtration. Concentrate to 120g, use reagent hydrochloric acid to adjust pH=3.5-3.7 (about 0.5mL is based on pH), and the concentrated solution is ready for use. Add 400mL of 85-95% ethanol aqueous solution to a 1000mL four-necked bottle, and add 2g of L-threo Raise the temperatur...

Embodiment 2

[0023] Take 40g (0.227mol) of vitamin C and add it to a 500mL three-neck flask, add 160mL of water, start stirring, slightly raise the temperature to 20-25°C, after the vitamin C is dissolved, cool down to 20-30°C, and slowly add 34g of heavy magnesium carbonate (0.34mol in terms of magnesium oxide (40%)), after the addition, cool down to 18-25°C, add 63.66g (28%, 0.524mol) of hydrogen peroxide dropwise (control the temperature at 18-25°C), after the addition, 18-25 Keep warm at ℃ for 2.5 hours, after the heat preservation is completed, raise the temperature to 50-55°C and keep it warm for 1 hour, then add 4.2g medicinal charcoal, raise the temperature to 70-75°C and continue to keep warm for 2 hours, after the heat preservation is completed, cool down to 25-30°C, filter with suction, and concentrate the filtrate to 120g, use reagent hydrochloric acid to adjust the pH to 3.5-3.7 (about 0.5mL is based on the pH), and the concentrated solution is ready for use. Add 400mL of 85-95...

Embodiment 3

[0025] Take 40g (0.227mol) of vitamin C and add it to a 500mL three-neck flask, add 160mL of water, start stirring, slightly raise the temperature to 20-25°C, after the vitamin C is dissolved, cool down to 20-30°C, and slowly add heavy magnesium carbonate 30.5 g (0.305mol based on magnesium oxide (40%)), after adding, cool down to 18-25°C, add 69g (28%, 0.567mol) of hydrogen peroxide dropwise (control the temperature at 18-25°C), dropwise, 18-25 Keep warm at ℃ for 2.5 hours, after the heat preservation is completed, raise the temperature to 50-55°C and keep it warm for 1 hour, then add 4.2g medicinal charcoal, raise the temperature to 70-75°C and continue to keep warm for 2 hours, after the heat preservation is completed, cool down to 25-30°C, filter with suction, and concentrate the filtrate to 120g, use reagent hydrochloric acid to adjust the pH to 3.5-3.7 (about 0.5mL is based on the pH), and the concentrated solution is ready for use. Add 400mL of 85-95% ethanol aqueous sol...

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Abstract

The invention discloses a synthesis method of magnesium L-threonate. According to the method, vitamin C is used as the raw material, hydrogen peroxide is used as an oxidant, and a heavy magnesium carbonate serving as a salt-forming agent is synthesized under a water system. Through optimization of crystallization conditions, the bulk density of magnesium L-threonate is higher than 0.6g / cm<3>, and the packed density of magnesium L-threonate is higher than 0.9g / cm<3>. According to the synthesis method of magnesium L-threonate, the low-cost heavy magnesium carbonate is used as the salt-forming agent, so that the synthesis cost is reduced; according to a later-stage crystallization optimizing technique, a concentrated solution is dropwise added into a micro-reflux of 85 percent to 95 percent of ethanol aqueous solution during crystallization; the magnesium L-threonate is high in bulk density; the market demand is met.

Description

Technical field [0001] The invention relates to a method for synthesizing magnesium L-threonate. Background technique [0002] L-threonate is widely found in plants, human gastric acid and uric acid. It is a degradation product of L-ascorbic acid. Magnesium is one of the essential elements for the survival of living organisms. Mg is very important for the activity of many enzyme functions. During normal metabolism in cells, the catalytic activity of several enzymes must rely on Mg. Magnesium L-L-threonate can be used as a Mg element supplement, a laxative and a choleretic, and its injection can also be used as an anticonvulsant. resolve resolution: [0003] [0004] The preparation method of magnesium L-threonate has been reported in Chinese Patent No. 201210388251 "A preparation method of L-threonate or its salt". It uses vitamin C as the raw material, hydrogen peroxide as the oxidant, and adds magnesium hydroxide salt-forming agent to the pure water system. The synth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/10C07C51/31C07C51/43
CPCC07C51/31C07C51/43C07C59/10
Inventor 刘爱凤龙中柱郭忠武张文文吴福忠蔡水洪
Owner 启东东岳药业有限公司
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