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Preparation technology and application of a kind of compound Haqing extract

A compound clam green and preparation process technology, which can be applied to medical preparations containing active ingredients, pharmaceutical formulations, medical raw materials derived from amphibians, etc., and can solve problems such as alcohol precipitation, impurity removal, adhesion, and increased production costs.

Active Publication Date: 2019-05-31
SHANXI JIANENG DAHUAYU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the actual production process, large quantities of Chinese herbal medicines are extracted, and the method of ethanol precipitation and impurity removal has many disadvantages: first, alcohol precipitation and impurity removal will cause different degrees of encapsulation during the operation of impurity removal. attached phenomenon, resulting in the loss of active ingredients
Second, the production cost is high, and in the recovery process of ethanol, alcohol consumption is large
Considering comprehensive economic benefits, the use of ethanol to remove impurities will increase production costs, and ethanol is volatile and potentially dangerous

Method used

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  • Preparation technology and application of a kind of compound Haqing extract
  • Preparation technology and application of a kind of compound Haqing extract
  • Preparation technology and application of a kind of compound Haqing extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] prescription:

[0027] Dried toad 1800g, astragalus 2250g, ginkgo 900g, aster 1125g, bitter almond 1125g, peucedanum 675g, attached slices 225g, southern schisandra 675g, black pepper 225g

[0028] crafting process:

[0029] (1) According to the prescription amount, the eight medicinal materials except toad are roughly crushed, and then the processed nine medicinal materials are put into the extraction tank, decocted with water for 3 times, and the amount of water added for the three times is 10 times, 5 times, 5 times respectively times, the decocting time is 3 hours, 2 hours, 1 hour respectively. After merging the extracts three times, the plate and frame are filtered, and the filtrate enters the double-effect concentration tank and is concentrated to a clear paste with a relative density of 1.2 (measured at 60°C), and then it is input into the storage tank with interlayer and serpentine pipe through the pipeline. Steam is introduced into the interlayer, and condens...

Embodiment 2

[0034] prescription:

[0035] Dried toad 180g, Astragalus 225g, Ginkgo 90g, Aster 112.5g, Bitter almond 112.5g, Peucedanum 67.5g, Fupian 22.5g, Schisandra 67.5g, Black pepper 22.5g.

[0036] crafting process:

[0037] (1) Coarsely crush the eight medicinal materials except toad according to the prescription amount, then put the processed nine medicinal materials into the extraction tank, add water for decoction twice, and add 5 times and 5 times of water each time, respectively, The decoction time is 2 hours and 1 hour each time. After the two extracts are combined, the plate and frame are filtered. The filtrate enters the double-effect concentration tank and is concentrated to a clear paste with a relative density of 1.23 (55 ° C). In the storage tank of the serpentine tube, the filtrate is heated by passing steam into the interlayer, and the condensed water is passed into the serpentine tube to control the temperature of the liquid medicine at 90 °C, and then add 20% of the...

Embodiment 3

[0041] prescription:

[0042] Dried toad 1800g, Astragalus 2250g, Ginkgo 900g, Aster 1125g, Bitter almond 1125g, Peucedanum 675g, Fupian 225g, Schisandra chinensis 675g, black pepper 225g.

[0043] crafting process:

[0044] (1) Coarsely crush the eight medicinal materials except toad according to the prescription amount, then put the processed nine medicinal materials into the extraction tank, add water to decoct 5 times, add 8 times, 6 times the amount of water each time, and finally Three times is 5 times the amount of water, and the decocting time is 3 hours, 2 hours, 1.5 hours, 1 hour, and 1 hour. After combining the extracts for five times, the plate and frame are filtered, and the filtrate is concentrated in a double-effect concentration tank to a relative density of 1.19 (63 ℃), the clear paste is input into the storage tank with interlayer and serpentine pipe through the pipeline, and the clear paste is heated by passing steam through the interlayer, and the temperat...

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Abstract

The invention provides a preparation technology of a compound Haqing extract and an application thereof. Nine medicines in a compound Haqing formula are extracted and the obtained extracted liquids are subjected to impurity removal in a manner of combination of a natural clarifying agent with water precipitation or alcohol precipitation, wherein the removal rate of protein the impurities is not less than 90%. According to production demands, the compound Haqing extract is matched with corresponding auxiliary materials so that solid preparations, such as tablets, capsules, granules and other solid preparations can be prepared through a certain technology process.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine compound preparations, in particular to a preparation process and application of compound clam green extract. Background technique [0002] The prescription of Compound Haqing Tablets is given in the Chinese Pharmacopoeia 2010 Edition: [0003] Dried toad 180g, Astragalus 225g, Ginkgo 90g, Aster 112.5g, Bitter almond 112.5g, Peucedanum 67.5g, Fupian 22.5g, Schisandra 67.5g, Black pepper 22.5g. [0004] In the traditional preparation process of Compound Haqing Tablets, the nine ingredients in the prescription need to be decocted with water, and after alcohol precipitation, the filtrate is concentrated into an extract, and then the corresponding medicinal excipients are added to make Compound Haqing Tablets, which have the function of invigorating Qi. Constricting the lungs, relieving cough and relieving asthma, warming the effect of phlegm retention. It is mainly used for waste-deficie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/79A61K36/736A61P11/14A61P11/06A61P11/10A61P11/00A61K35/65
Inventor 耿福能
Owner SHANXI JIANENG DAHUAYU PHARMA CO LTD