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Application of lung cancer metabolism markers to lung cancer diagnosis and treatment

A technology of metabolic markers and metabolites, applied in biological testing, material inspection products, measuring devices, etc., can solve the problems of low accuracy and single evaluation index

Inactive Publication Date: 2015-11-04
HUZHOU CENT HOSPITAL
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Problems solved by technology

Although recent studies have found that the detection of superoxide dismutase and monoamine oxidase combined with enzymes has certain significance for the diagnosis of lung cancer, the serum SOD activity of lung cancer patients is significantly lower than that of benign lung lesions and normal healthy people, but due to its single evaluation index and low accuracy, it is necessary to Combined with other indicators for diagnosis

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  • Application of lung cancer metabolism markers to lung cancer diagnosis and treatment
  • Application of lung cancer metabolism markers to lung cancer diagnosis and treatment
  • Application of lung cancer metabolism markers to lung cancer diagnosis and treatment

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[0027] 1. General information: From January 2012 to January 2013, 30 patients with lung cancer diagnosed by pathology or cytology in Huzhou Central Hospital, aged 43-76 years, with an average age of 63.9 years; 21 cases were male and 9 cases were female ; There were 15 cases of adenocarcinoma, 12 cases of squamous cell carcinoma, and 3 cases of large cell lung cancer. The control group included 30 cases, all of whom had normal physical examination in Huzhou City, aged 39-78 years, with an average of 60.4 years; 19 cases were male and 11 cases were female. This study was approved by the Ethics Committee of Huzhou Central Hospital, and all subjects gave informed consent to participate in this study.

[0028] 2. Specimen collection: Collect 5ml of fasting blood samples from healthy and normal subjects and lung cancer patients before surgery, put them in sterile coagulation-promoting BD vacuum blood collection tubes, centrifuge at 2500r / min, 4°C for 5min, take the upper serum, and...

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Abstract

The invention relates to the technical field of medical diagnostics, in particular to the field of tumor diagnosis. By analyzing the concentration of small-molecule metabolites in blood of a normal person, blood of a person before a lung cancer operation is carried out, and blood of a person after the lung cancer operation is carried out, multiple metabolism markers which can be used for monitoring the lung cancer curative effect and multiple metabolism markers which can be used for lung cancer diagnosis are screened out. The method has the advantages of being high in sensitivity and flux, and applicable to lung cancer screening and auxiliary diagnosis.

Description

technical field [0001] The invention relates to the technical field of medical diagnostics, in particular to the field of tumor diagnosis. Background technique [0002] Cancer remains one of the deadliest threats to human health. Solid tumors are responsible for most of these deaths. Although significant advances have been made in the medical treatment of certain cancers, overall 5-year survival rates for all cancers have only improved by about 10% in the last 20 years. Cancer, or malignancy, grows and metastasizes rapidly in an uncontrolled manner, making timely detection and treatment extremely difficult. In the past 30 years, with the influence of external factors such as air pollution and smoking, the incidence of lung cancer in my country has also increased day by day. In Shanghai, Beijing and Tianjin, it is indeed the first place among various malignant tumors. The premise of treatment is based on a clear diagnosis. Early diagnosis of lung cancer is a difficult and ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48G01N30/88
Inventor 钟婧郑淑莺戴利成
Owner HUZHOU CENT HOSPITAL
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