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Construction method and equipment for SCI (spinal cord injury) animal model

An animal model and spinal cord injury technology, which is applied in medical science, veterinary instruments, veterinary surgery, etc., can solve problems that cannot completely simulate human spinal cord injury

Inactive Publication Date: 2015-12-16
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method proposed in this utility model patent cannot fully simulate the effect of human spinal cord injury by impacting from the experimental model

Method used

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  • Construction method and equipment for SCI (spinal cord injury) animal model
  • Construction method and equipment for SCI (spinal cord injury) animal model
  • Construction method and equipment for SCI (spinal cord injury) animal model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Such as Figure 1~2 The construction equipment shown for preparing the animal model of spinal cord injury includes an operating platform 1, a column 2 and a beam 3, wherein:

[0059] The upper surface of the operating platform 1 is provided with limb fixing clips 11;

[0060] The column 2 stands on the side of the operating platform 1, and the column 2 is connected to the crossbeam 3, on which the elevating rod 4 is vertically suspended, and the bottom of the elevating rod 4 is connected with an "L" shaped pressing rod 5. During the experiment, the limbs of the experimental animal are first clamped by the limb fixing clips 11, fixed on the operating platform 1, the dorsal skin of the experimental animal is cut, the subcutaneous tissue is separated layer by layer, and the spinous processes of the 9-10 vertebral body are exposed Finally, place a miniature rongeur in the intervertebral space, bite off the lateral vertebrae, expose the spinal cord, and then insert the "L"-...

Embodiment 2

[0068] Such as Figure 3-7 The construction equipment shown for preparing the animal model of spinal cord injury includes an operating platform 1, a column 2 and a beam 3, wherein:

[0069] The upper surface of the operating platform 1 is provided with limb fixing clips 11;

[0070] The column 2 stands on the side of the operating platform 1, and the column 2 is connected to the crossbeam 3, on which the elevating rod 4 is vertically suspended, and the bottom of the elevating rod 4 is connected with an "L" shaped pressing rod 5. During the experiment, the limbs of the experimental animal are first clamped by the limb fixing clips 11, fixed on the operating platform 1, the dorsal skin of the experimental animal is cut, the subcutaneous tissue is separated layer by layer, and the spinous processes of the 9-10 vertebral body are exposed Finally, place a miniature rongeur in the intervertebral space, bite off the lateral vertebrae, expose the spinal cord, and then insert the "L"-...

Embodiment 3

[0075] All the other are with embodiment 2, as Figure 8-9 The shown construction equipment for preparing the animal model of spinal cord injury, wherein the suspension mode of the beam 3 and the lifting rod 4 is specifically:

[0076] The cross beam 3 is longitudinally provided with a through hole 34, and the through hole 34 is provided with a thread groove;

[0077] The outer surface of the lifting rod 4 is provided with an external thread, and the external thread of the lifting rod 4 cooperates with the thread groove of the through hole 34;

[0078] The outer surface of the lifting rod 4 is provided with a scale line 45 .

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Abstract

The invention relates to the technical fields of construction of experimental animal models and laboratory instruments, and particularly relates to a construction method and construction equipment for an SCI (spinal cord injury) animal model. The construction equipment comprises an operation platform, uprights and a cross beam, wherein the four-limbs fixing clips are arranged on the upper surface of the operation platform; the uprights are arranged on the side edges of the operation platform, and connected with the cross beam, a lifting rod is vertically hung on the cross beam, and the bottom of the lifting rod is connected with an L-shaped pressing rod. The method and the equipment have the beneficial effects that during the clinic practical work, the original experimental method of striking and pressing from the ventral and from outside the of the spinal cord is changed into the method of pulling outwards from the inner side of the spinal cord of the experimental animal to stimulate the spinal cord compression injury degree, so that the spinal cord injury situation of people is better stimulated.

Description

technical field [0001] The invention relates to the technical field of experimental animal model construction and laboratory instrument technology, in particular to a construction method and construction equipment of a spinal cord injury animal model. Background technique [0002] With the rapid development of the transportation industry and the construction industry, the incidence of spinal cord injury (Spinal Cord Injury, SCI) is increasing year by year. According to statistics, the incidence rate of spinal cord injury in the world is as high as 23%, and there are about 180,000 new cases every year. In the United States, there were 12,400 new cases in 2010 alone. It is estimated that by 2050, the number of people with spinal cord injury may exceed 17,560, and its severe disability has brought a heavy burden to families and society. [0003] Due to the complex pathophysiological mechanism after spinal cord injury, the current treatment effect is not ideal. To study the me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 苏佳灿张军陈晓曹烈虎
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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