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Kit for benign lesion identification and malignant lesion detection of oral mucosa and detection method thereof

A detection kit and oral mucosa technology, which are applied in the field of benign lesions investigation and malignant lesion detection kits of oral mucosa, can solve problems such as affecting early diagnosis, difficult for early introduction of patients, and promoting transfer.

Active Publication Date: 2015-12-23
美泰克斯商贸(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is direct and accurate, but because it is invasive, it may promote metastasis, and the oral lesion tissue is small, and false negatives may occur due to site deviation during sampling and sectioning. Therefore, this method is not easy to be introduced to patients early, which will affect early diagnosis.

Method used

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  • Kit for benign lesion identification and malignant lesion detection of oral mucosa and detection method thereof
  • Kit for benign lesion identification and malignant lesion detection of oral mucosa and detection method thereof
  • Kit for benign lesion identification and malignant lesion detection of oral mucosa and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1). Oral examination, record the details of the lesion;

[0035] (2). Gargle with clean water to remove food residues;

[0036] (3). Take the pre-test reagent and rinse for 1 to 5 minutes;

[0037] (4). Dip the detection reagent 1 with a cotton swab and rub it on the lesion, and stain for 2 to 10 minutes;

[0038] (5). Take the detection reagent 2 and rinse for 1 to 5 minutes;

[0039] (6). Semi-quantitative or quantitative evaluation of staining results by comparison with color guides or auto-excited fluorescence detection instruments.

[0040] The phosphate buffer mentioned above is 0.01M, and the preparation method is as follows:

[0041] Weigh 7.9gNaCl, 0.2gKCl, 1.44gNa2HPO4 and 1.8gK at a temperature of 0-4°C 2 Dissolve HPO4 in 800ml of distilled water, adjust the pH value of the solution to 7.4 with HCl, and finally add deionized water to make it up to 1L, and store it in a refrigerator at 4°C for later use.

[0042] The preparation method of the above-menti...

Embodiment 2

[0045] (1). Oral examination, record the details of the lesion;

[0046] (2). Gargle with clean water to remove food residues;

[0047] (3). Take the pre-test reagent and rinse for 1 to 5 minutes;

[0048] (4). Dip the detection reagent 1 with a cotton swab and rub it on the lesion, and stain for 2 to 10 minutes;

[0049] (5). Take the detection reagent 2 and rinse for 1 to 5 minutes;

[0050] (6). Semi-quantitative or quantitative evaluation of staining results by comparison with color guides or auto-excited fluorescence detection instruments.

[0051] The phosphate buffer mentioned above is 0.01M, and the preparation method is as follows:

[0052] At a temperature of 0-4°C, weigh 7.9gNaCl, 0.2gKCl, 0.24gKH 2 PO4 and 1.8gK 2 Dissolve HPO4 in 800ml of distilled water, adjust the pH value of the solution to 7.4 with HCl, and finally add deionized water to make it up to 1L, and store it in a refrigerator at 4°C for later use;

[0053]The preparation method of the above-men...

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Abstract

The invention provides a kit for benign lesion identification and malignant lesion detection of the oral mucosa and a detection method thereof. The detection method comprises the following steps that 1, oral cavity examination is performed, and detailed information of lesions is recorded; 2, the mouth is rinsed with clean water to remove food debris; 3, a preexamination reagent is taken for gargling for 1-5 minutes; 4, a first examination reagent is taken in a dipping mode with a cotton swab to be embrocated on the partial lesions, and dyeing is performed for 2-10 minutes; 5, a second examination reagent is taken for gargling for 1-5 minutes; 6, semi-quantitative or quantitative evaluation is performed on the dyeing results by comparing the dyeing results with a color plate or a self-excitated fluorescence detecting instrument. The kit can be used for auxiliary differential diagnosis of the benign lesion and the malignant lesion of the oral mucosa and can assist a clinician to early diagnose an oral cavity cancer and monitor the malignant process of the oral precancerous lesions.

Description

technical field [0001] The invention relates to a detection device kit, in particular to a detection kit for benign lesions and malignant lesions of oral mucosa and a detection method thereof. Background technique [0002] Oral cancer refers to malignant tumors that occur in the oral cavity, including lip cancer, gum cancer, tongue cancer, soft and hard palate cancer, jaw cancer, mouth floor cancer, oropharyngeal cancer, salivary gland cancer and maxillary sinus cancer, as well as facial skin cancer. Mucous membrane cancer, etc. Oral cancer is one of the more common malignant tumors of the head and neck. Currently, there are two types of diagnostic techniques for oral cancer and precancerous lesions: [0003] 1. Invasive technique: that is, histopathological method. It is necessary to remove the diseased tissue of the patient, and then slice it under a microscope to observe the tissue lesion. This method is direct and accurate, but because it is invasive, it may promote met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/30G01N21/25G01N21/64
Inventor 李成章陈汉正杜格非
Owner 美泰克斯商贸(北京)有限公司
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