A kind of preparation method of veterinary telamectin microsphere

A tyramectin and microsphere technology, which is applied in the field of preparation of veterinary tyramectin microspheres, can solve the problems of teramectin limitation, cardiotoxicity, negative cardiac force, etc., and achieves less harsh storage conditions and toxicity Small, easy to store effect

Active Publication Date: 2018-06-22
河南后羿制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But at the same time, as an antibiotic, telamectin is also irritating to the body to a certain extent, sometimes causing allergic reactions, and in severe cases, it is very toxic to the heart. Too fast and large doses of intravenous or intramuscular injection may cause negative heart force, cause animal death
Therefore, telamectin is mainly administered by oral administration or subcutaneous injection, which limits the clinical promotion of telamectin in veterinary medicine.

Method used

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  • A kind of preparation method of veterinary telamectin microsphere
  • A kind of preparation method of veterinary telamectin microsphere

Examples

Experimental program
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Embodiment 1

[0029] A preparation method for veterinary telamectin microspheres, comprising the steps of:

[0030] The first step is to configure the solution

[0031] a. Preparation of water phase: under stirring, weigh dextran and telamectin, the weight ratio of said telamectin to dextran is (0.5-1): 1, add water and heat to dissolve completely to obtain water phase; the concentration of dextran in the aqueous phase is 0.15 ~ 0.2g / ml;

[0032] b. Preparation of the oil phase: under stirring, measure the castor oil, the volume ratio of the castor oil to the amount of water added in step a is (8-10): 1, add an emulsifier, the add-on amount of the emulsifier It is 1-1.5% of the volume of castor oil, heated and stirred to dissolve completely to obtain an oil phase, and the temperature of the oil phase is 55-65°C;

[0033] Step 2 Preparation of Microspheres

[0034] c. Under stirring, keep the oil phase at 55-65°C, add the water phase to the oil phase drop by drop, and then continue to hea...

Embodiment 2

[0043] The preparation method of the telamectin microspheres of the present embodiment comprises the following steps:

[0044] The first step is to configure the solution

[0045] a. Preparation of the water phase: under stirring, weigh 1 g of dextran and 1 g of telamectin, add 5 ml of distilled water and heat to dissolve to completely obtain the water phase; the concentration of the dextran in the water phase is 0.2 g / ml;

[0046] b. Preparation of the oil phase: under stirring, measure 50ml of castor oil, add 0.6ml of Span-80, heat and stir in a water bath to dissolve completely to obtain an oil phase, and the temperature of the oil phase is 60°C;

[0047] Step 2 Preparation of Microspheres

[0048] c. Under stirring, keep the oil phase at 60°C, add the water phase to the oil phase drop by drop, and then continue to heat and stir for 10 minutes to obtain an emulsion;

[0049] d. Cool the emulsion obtained in step c to 5°C for 20 minutes, then add pre-cooled acetone to dehy...

Embodiment 3

[0052] The first step is to configure the solution

[0053] a. Preparation of the water phase: under stirring, weigh 0.9g dextran and 0.7g telamectin, add 5ml of distilled water and heat to dissolve completely to obtain the water phase; the concentration of the dextran in the water phase is 0.18g / ml;

[0054] b. Preparation of the oil phase: under stirring, measure 40ml of castor oil, add 0.6ml of Span-80, heat and stir in a water bath to dissolve completely to obtain an oil phase, and the temperature of the oil phase is 65°C;

[0055] Step 2 Preparation of Microspheres

[0056] c. Under stirring, keep the oil phase at 65°C, add the water phase to the oil phase drop by drop, and then continue to heat and stir for 10 minutes to obtain an emulsion;

[0057]d. Cool the emulsion obtained in step c to 10°C for 20 minutes, then add pre-cooled acetone to dehydrate at 10°C, stir for 13 minutes and filter with suction, wash the filter residue three times with acetone to obtain powde...

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Abstract

The invention relates to a preparing method for draxxin microspheres for livestock. The method comprises the steps that glucan is used for wrapping and sealing draxxin medicine to prepare the microspheres, firstly, a water phase containing glucan and draxxin and an oil phase containing an emulsifying agent are prepared, and the water phase and the oil phase are evenly mixed at 55-65 DEG C; secondly, the temperature of the mixed solution is reduced to 5-10 DEG C; thirdly, a dehydrating agent is added, un-cross-linked microspheres obtained after stirring and filtering are subjected to cross-linking in a cross-linking agent, and the draxxin microspheres are obtained. The draxxin microspheres prepared through the method are mainly concentrated in the lungs in animal bodies after being taken, good targeting is achieved, treatment can be performed oriented to the bacterial infection of the lungs of the animals, and a good curative effect is achieved. In addition, the preparing method is simple, low in energy consumption, small in toxicity, high in safety and free of the need for special equipment, and the finally-prepared draxxin microspheres have high encapsulation efficiency, and is low in preparing cost and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a preparation method of telamectin microspheres for veterinary use. Background technique [0002] Tulathromycin, English name Tulathromycin, also known as Tulathromycin, tulathromycin, tolathromycin. Its chemical structural formula is shown in Formula 1, and its molecular formula is C 41 h 79 N 3 o 12 . [0003] [0004] Formula 1 Tyramectin [0005] Tyramectin is a new type of erythromycin semi-synthetic veterinary antibiotic developed by Pfizer Animal Health in the late 1990s, and belongs to the third generation of macrolide antibiotics. It is mainly used for the treatment and prevention of porcine and bovine respiratory diseases caused by Actinobacillus pleuropneumoniae, Mycoplasma, Pasteurella, Haemophilus para, Bordetella bronchiseptica, etc. [0006] Tyramectin contains three basic air groups, which are strongly negatively charged in soluti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/7052A61K47/36A61P31/04
Inventor 张听盼姚德新
Owner 河南后羿制药有限公司
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