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Ligularia virgaurea extract and preparation method and application thereof in aspect of reducing blood glucose

An extract and a technology of A. japonica, applied in the field of an extract of A. japonicus and its preparation, can solve the problems such as less research on hypoglycemic effect, no research and report of H. japonicus, etc., and achieve sufficient technical raw materials, Reduced activity, widely distributed effect

Active Publication Date: 2016-01-20
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are about 112 species of plants in the genus Ligularia in my country, most of which are distributed in the Qinghai-Tibet Plateau, and many of them have medicinal value. Related Research and Reports

Method used

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  • Ligularia virgaurea extract and preparation method and application thereof in aspect of reducing blood glucose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation method of the leaf extract of Ligularia fruticosa of the present invention is as follows:

[0017] The fresh leaves of Lignus chinensis in the mature stage collected in August in Gannan area were dried in the shade and pulverized, and passed through a 100-mesh sieve to obtain fine powder. The leaf fine powder is extracted with 20 times absolute ethanol solution, ultrasonically extracted for 60 minutes, repeated extraction 3 times, and concentrated under reduced pressure at a temperature lower than 40°C. Dry it in a dark, low-temperature and well-ventilated place to prepare the extract. The extract is a dark green solid.

Embodiment 2

[0019] The preparation method of Ligwu root extract of the present invention is as follows:

[0020] The fresh roots of Lignus chinensis collected in August in the Gannan area at the mature stage were dried in the shade and crushed, and passed through a 100-mesh sieve to obtain a fine powder. The leaf fine powder is extracted with 20 times absolute ethanol solution, ultrasonically extracted for 60 minutes, repeated extraction 3 times, and concentrated under reduced pressure at a temperature lower than 40°C. Dry it in a dark, low-temperature and well-ventilated place to prepare the extract. The extract is a black solid.

Embodiment 3

[0022] The preparation method of Lignus chinensis flower extract of the present invention is as follows:

[0023] The fresh flowers (yellow) of Lignus chinensis collected in August in the Gannan area at the mature stage were dried in the shade and crushed, and passed through a 100-mesh sieve to obtain fine powder. The leaf fine powder is extracted with 20 times absolute ethanol solution, ultrasonically extracted for 60 minutes, repeated extraction 3 times, and concentrated under reduced pressure at a temperature lower than 40°C. Dry it in a dark, low-temperature and well-ventilated place to prepare the extract. The extract is dark brown viscous solid.

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Abstract

The invention provides an extraction and preparation method of ligularia virgaurea components. The invention further provides application of prepared ligularia virgaurea extract in reducing the activity of glucosidase and treating diabetes. The prepared ligularia virgaurea extract serves as a plant source drug and can effectively reduce the activity of the glucosidase, and side effects are small; not only is a novel treatment means provided for diabetes treatment, but also the grassland poisonous weed resource of ligularia virgaurea is scientifically, reasonably and sustainably developed and utilized, a harmful thing is turned into treasure, and meanwhile important significance to protection of the ecological environment of the Tibet plateau is achieved. According to the ligularia virgaurea extract and the preparation method and application in the aspect of reducing the blood glucose, the preparation technology is simple, rapid and environmentally friendly, and due to the fact that the plant resources are rich, low in development cost and capable of being continuously developed, the economic benefit is obvious.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to an extract of Ligularia fruticosa and its preparation method and application in treating diabetes. Background technique [0002] Diabetes mellitus is a metabolic disease associated with abnormal insulin production and action and characterized by hyperglycemia, for which there is no cure. Recent studies have found that in the onset of diabetes, postprandial hyperglycemia often occurs first, and then develops into diabetes, that is, the former is an early sign of the latter. For diabetic patients, especially type Ⅱ patients, postprandial hyperglycemia is far more harmful to the body than fasting hyperglycemia. Postprandial hyperglycemia stimulates the pancreas to secrete a large amount of insulin, which can cause various metabolic abnormalities and vascular lesions, and at the same time make the pancreas Functionality is further compromised. Therefore, redu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P3/10
Inventor 刘权王有年李晓蓓
Owner LANZHOU UNIVERSITY