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A kind of cell complex for periodontal tissue repair and its application

A periodontal tissue and complex technology, which is applied to the field of periodontal tissue repair cell complexes and their preparation, can solve problems such as large body trauma, low stem cell content, and not seed cells, and achieves reduced trauma, rich sources, and effective effects. obvious effect

Active Publication Date: 2018-09-04
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that bone marrow stromal stem cells can repair periodontal tissue, but bone marrow needs to be obtained through bone puncture, which will cause greater physical trauma to the body. Amplification over time, not good seed cells

Method used

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  • A kind of cell complex for periodontal tissue repair and its application
  • A kind of cell complex for periodontal tissue repair and its application
  • A kind of cell complex for periodontal tissue repair and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1, Cell Complex for Periodontal Tissue Repair

[0020] In this embodiment, the cell complex used for periodontal tissue repair per milliliter contains 2.5×10 umbilical cord mesenchymal stem cells. 4 , periodontal ligament mesenchymal stem cells 2.5×10 4 One, the mass volume percentage of human serum albumin (Austria Baxter International Co., Ltd.) is 1.5%, and the balance is normal saline.

Embodiment 2

[0021] Example 2, Cell Complex for Periodontal Tissue Repair

[0022] In this embodiment, each milliliter of the cell complex used for periodontal tissue repair contains 0.5×10 umbilical cord mesenchymal stem cells 4 , periodontal ligament mesenchymal stem cells 5×10 4 One, the mass volume percentage of human serum albumin is 2%, and the balance is normal saline.

Embodiment 3

[0023] Example 3, Cell Complex for Periodontal Tissue Repair

[0024] In this embodiment, each milliliter of the cell complex used for periodontal tissue repair contains 5×10 umbilical cord mesenchymal stem cells 4 , periodontal ligament mesenchymal stem cells 0.5×10 4 One, the mass volume percentage of human serum albumin is 1%, and the balance is normal saline.

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Abstract

The invention discloses a cell complex used for periodontal tissue repairing, and applications thereof. The cell complex comprises 0.5*10<4> to 5*10<4> / ml human umbilical cord mesenchymal stem cells and 0.5*10<4> to 5*10<4> / ml periodontal ligament mesenchymal stem cells. The cell complex can be used for preparing drugs used for periodontal tissue repairing. The cell complex composed of human umbilical cord mesenchymal stem cells and periodontal ligament mesenchymal stem cells is capable of inhibiting expression of inflammatory factors obviously, and possesses obvious effects on periodontal tissue repairing.

Description

technical field [0001] The invention relates to the field of periodontal tissue repair, in particular to a cell complex for periodontal tissue repair and its preparation method and application. Background technique [0002] Periodontal disease is an inflammatory disease of tooth supporting tissues including periodontal ligament and cementum. It is a common oral disease that seriously endangers human teeth and general health. The purpose of its treatment is to eliminate local inflammation of periodontal tissue and regenerate it. and rebuild the periodontal tissue destroyed by verification. In vivo studies have shown that the concentrations of IL-1 and TNF-α at the site of periodontal inflammation are significantly increased, while their concentrations are significantly decreased after successful treatment. Therefore, the use of antagonists of IL-1 and TNF-α may reduce the concentration of IL-1 and TNF-α, reduce the damage of periodontal tissue, and promote the progress of re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/38A61L27/22A61K35/28A61P1/02
Inventor 王一飞陈海佳葛啸虎马岩岩王小燕
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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