Traditional Chinese medicine composition for treatment of Parkinson's disease

A Parkinson's disease and composition technology, applied in the field of traditional Chinese medicine composition, can solve the problems of increasing free radicals in the brain, damaging dopamine neurons, and large economic burdens, and achieves improved behavior of rolling sticks, precise compatibility, and improved The effect of content

Inactive Publication Date: 2016-01-27
SHANGHAI ZICAO MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] ①Long course of disease: Although PD does not affect life expectancy, patients generally still need to take medicine for life
[0008] ③Great social harm: patients not only partially lose their ability to work, but also have to endure lifelong drug treatment and bear a huge economic burden, which shows that it is extremely harmful to society
However, long-term use of the drug can cause severe side effects such as dyskinesia, end-of-dose phenomenon, and "switching" phenomenon, and can increase the generation of free radicals in the brain and damage dopamine neurons.
In addition, from the perspective of intellectual property rights, almost all domestic PD drugs are imitation varieties, seriously lacking independent intellectual property rights

Method used

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  • Traditional Chinese medicine composition for treatment of Parkinson's disease
  • Traditional Chinese medicine composition for treatment of Parkinson's disease
  • Traditional Chinese medicine composition for treatment of Parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh raw materials: Bupleurum 10g, Rehmannia glutinosa 10g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 10g. Add 6 times the amount of water to decoct and extract 3 times, each time for 1 hour, filter, combine the filtrate and concentrate under reduced pressure to 1.10-1.12, add appropriate amount of auxiliary materials to mix, add water to adjust to 200ml, and make a mixture.

Embodiment 2

[0037] Weigh raw materials: Bupleurum 50g, Rehmannia glutinosa 100g, Radix Paeoniae Alba 50g, Radix Glycyrrhizae 50g. Add 8 times the amount of water to decoct and extract twice, each time for 1 hour, filter, combine the filtrate and concentrate under reduced pressure to 1.20-1.22, vacuum-dry to obtain the dry extract, grind it, add appropriate amount of auxiliary materials and mix well, and make tablets, each tablet 0.5g.

Embodiment 3

[0039] Weigh raw materials: Bupleurum 25g, Rehmannia glutinosa 50g, Radix Paeoniae Alba 25g, Radix Glycyrrhizae 25g. Add 8 times the amount of water to decoct and extract twice, each time for 1 hour, filter, combine the filtrates and concentrate under reduced pressure to 1.20-1.25, vacuum-dry, add appropriate amount of auxiliary materials to granulate, fill to obtain granules, each bag is 10g.

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Abstract

The invention discloses a traditional Chinese medicine composition for treatment of Parkinson's disease, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition for treatment of Parkinson's disease is prepared from radix bupleuri, prepared rehmannia root, radix paeoniae alba and liquorice according to a certain weight part proportion. An MPTP induced mice subacute Parkinson's disease model proves that the traditional Chinese medicine composition has the effect of improving symptoms of mice Parkinson's disease.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating Parkinson's disease. Background technique [0002] Parkinson's disease (Parkinson disease, PD), also known as Parkinson's paralysis, is a chronic neurodegenerative disease, and its pathological feature is the degeneration and death of dopaminergic neurons in the nigrostriatal system of the midbrain, resulting in the neurotransmitter of dopamine in the brain. clinical manifestations such as resting tremor, muscle rigidity, and decreased movement. [0003] PD was first described by British doctor Parkinson in 1817, but its exact pathogenesis is still not very clear. Now it is found that the factors related to its pathogenesis mainly include age factor, environmental factor and genetic factor. [0004] In industrialized countries, the prevalence of PD is estimated at 0.3% of the general population and 1% of the soc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P25/14
Inventor 王赛香
Owner SHANGHAI ZICAO MEDICINE TECH CO LTD
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