Traditional Chinese medicine preparation for treating Parkinson's disease

A technology of traditional Chinese medicine preparation and Parkinson's disease, which is applied in the field of Chinese medicine preparations for the treatment of Parkinson's disease, can solve the problems of damaging dopamine neurons, increasing the generation of free radicals in the brain, and causing great social harm, so as to increase content, improve pole climbing and The Effects of Rotating Rod Behavior

Inactive Publication Date: 2015-09-23
SHANGHAI RUIYANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] ①Long course of disease: Although PD does not affect life expectancy, patients generally still need to take medicine for life
[0007] ③Great social harm: patients not only partially lose their ability to work, but also have to endure lifelong drug treatment and bear a huge economic burden, which shows that it is extremely harmful to society
However, long-term use of this drug can cause severe side effects such as dyskinesia, end-of-dose phenomenon, and "switching" phenomenon, and can increase the generation of free radicals in the brain and damage dopamine neurons

Method used

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  • Traditional Chinese medicine preparation for treating Parkinson's disease
  • Traditional Chinese medicine preparation for treating Parkinson's disease
  • Traditional Chinese medicine preparation for treating Parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1: Preparation of decoction

[0065] Weigh the raw materials: Uncaria 10g, Rehmannia glutinosa 10g, Angelica 50g, Radix Paeoniae Rubra 10g, and Anemarrhena vulgaris 10g. Add 6 times the weight of water to decoct and extract 3 times, 1 hour each time, filter, combine the filtrate under reduced pressure and concentrate until the relative density of the solution is 1.10~1.12, add appropriate amount of auxiliary materials and mix well, add water to adjust to 200ml, make a decoction .

Embodiment 2

[0066] Example 2: Preparation of tablets

[0067] Weigh out the raw materials: Uncaria Uncaria 50g, Rehmannia glutinosa 75g, Angelica 100g, Radix Paeoniae Rubra 50g, Zhimu 50g. Add 6 times the weight of water to decoct and extract 3 times, 1 hour each time, filter, combine the filtrate under reduced pressure and concentrate until the relative density of the liquid is 1.10~1.12, vacuum dry to obtain the dry extract and pulverize, add appropriate amount of auxiliary materials and mix. Make tablets, each 0.5g.

Embodiment 3

[0068] Example 3: Preparation of granules

[0069] Weigh the raw materials: Uncaria 25g, Rehmannia glutinosa 50g, Chinese angelica 50g, Radix Paeoniae Alba 25g, and Anemarrhena vulgaris 25g. Add 6 times the weight of water to decoct and extract 3 times, 1 hour each time, filter, combine the filtrate under reduced pressure and concentrate until the relative density of the liquid is 1.10~1.12, vacuum dry, add appropriate amount of auxiliary materials to granulate, fill to obtain granules , 10g per bag.

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Abstract

The invention relates to a traditional Chinese medicine preparation for treating Parkinson's disease, and belongs to the traditional Chinese medicine pharmaceutical technical field. The traditional Chinese medicine preparation is composed of uncaria rhynchophylla, prepared rehmannia root, angelica sinensis, radix paeoniae alba, rhizoma anemarrhenae and the like; the raw material drugs of the traditional Chinese medicine preparation are added with regular auxiliary materials and can be made into a decoction, granules, tablets, capsules or other traditional Chinese medicine oral preparations according to a conventional method. The traditional Chinese medicine preparation has a significant effect on stick rotation and pole climbing ethology of an MPTP induced subacute PD mouse model, can improve the content of dopamine in corpora striatum of model mice, and can be used in treatment of Parkinson's disease.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating Parkinson's disease, and belongs to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Parkinson's disease (PD), also known as tremor paralysis, is a chronic neurodegenerative disease. Its pathological feature is the degeneration and death of dopaminergic neurons in the substantia nigra striatum of the midbrain, leading to dopamine in the brain Neurotransmitters are reduced, and clinical symptoms such as resting tremor, muscle stiffness, and reduced movement appear. PD was first described by British doctor Parkinson in 1817, but its exact pathogenesis is still not very clear. Now it is found that the factors related to its pathogenesis are mainly age factors, environmental factors and genetic factors. [0003] In industrialized countries, the prevalence of PD is estimated to be 0.3% of the total population and 1% of the social population ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P25/16
Inventor 汤爱华
Owner SHANGHAI RUIYANG BIOTECH CO LTD
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