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Perfluorodecalin emulsion and preparation method thereof

A technology of perfluorodecalin and emulsion, which is used in emulsion delivery, medical preparations with non-active ingredients, blood diseases, etc., can solve the problems of HIV virus, hepatitis virus infection, unstable blood supply, and endangering the health of patients. , to achieve the effect of stable properties, good preparation effect and good metabolic performance

Inactive Publication Date: 2016-02-03
金丽玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional blood sources rely on citizen blood donations and genetically modified animals. Not only is the blood supply unstable, but it also faces various risks: the HIV virus and hepatitis virus in the blood source may be infected; Small air bubbles will endanger the health of the patient; when the patient needs hyperoxic therapy, the oxygen-carrying capacity of ordinary blood is not satisfactory

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A kind of preparation method of perfluorodecalin emulsion of the present invention, is made up of following steps:

[0013] (1) Add 400g of egg yolk phospholipid and 400mg of sodium palmitate into the 8.5LLactatedRingen solution, and stir evenly to obtain the phospholipid dispersed phase;

[0014] (2) Add 2.5 kg of perfluorodecalin to the phospholipid dispersed phase and stir vigorously for 30 minutes to obtain a crude perfluorodecalin emulsion;

[0015] (3) Add the crude perfluorodecalin emulsion into the stirring tank to pass through the 50MPa double valve for emulsification. First, fix the second layer valve to keep the pressure at 10MPa, then fix the first layer valve until the pressure rises to 50MPa, and keep the temperature at 50 ±5°C until a stable emulsion is obtained;

[0016] (4) After distributing the above emulsion into reagent bottles, sterilize at 100°C for 30 minutes to obtain the product. The content of perfluorodecalin in the above emulsion is 27.3%, ...

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Abstract

The invention discloses a preparation method of a perfluorodecalin emulsion. The method includes: adding 400g of yolk phospholipid and 400mg of sodium palmitate into 8.5L of Lactated Ringen solution, and evenly stirring to obtain a phospholipid dispersed phase; adding 2.5kg of perfluorodecalin into the phospholipid dispersed phase, and stirring hard for 30 minutes to obtain a coarse perfluorodecalin emulsion; adding the coarse perfluorodecalin emulsion into a stirring tank and allowing the coarse perfluorodecalin emulsion to pass double valves of 50MPa for emulsifying, to be more specific, fixing the second-layer valve to keep the pressure intensity at 10MPa, fixing the first-layer valve until the pressure rises to 50MPa, and keeping temperature at 50+ / -5 DEG C until the stable emulsion is obtained; split charging the stable emulsion into reagent bottles, and sterilizing for 30 minutes under 100 DEG C to obtain the perfluorodecalin emulsion. The perfluorodecalin emulsion has the advantages that the oxygen carrying capacity of the perfluorodecalin emulsion is 30 times of compound volume, and the perfluorodecalin emulsion is free of toxic and side effects on human bodies and animals, free of residues, stable in property and capable of being used as artificial blood for injection.

Description

technical field [0001] The invention relates to a preparation method of artificial blood, in particular to a preparation method of perfluorodecalin emulsion. Background technique [0002] In the face of sudden blood needs such as trauma and surgery, external blood transfusions are often required. However, traditional blood sources rely on citizen blood donations and genetically modified animals. Not only is the blood supply unstable, but it also faces various risks: the HIV virus and hepatitis virus in the blood source may be infected; Small air bubbles will endanger the health of the patient; when the patient needs hyperoxic therapy, the oxygen-carrying capacity of ordinary blood is not satisfactory. Artificial blood came into being under the impetus of these problems. Scientific research has found that the oxygen-carrying function of perfluorodecalin is 20 to 30 times that of human blood. Therefore, how to use perfluorodecalin as a safe artificial blood to replace human ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/025A61K47/24A61P7/06
Inventor 金丽玲
Owner 金丽玲