Tissue repair scaffold and preparation method and use thereof

Abstract

The invention provides a tissue repair bracket and its preparation method and application. The tissue repair scaffold includes at least one composite fiber layer, and the composite fiber layer includes composite fibers composed of adhesion factors and hydrophobic synthetic materials. The composite fiber layer can further form a porous three-dimensional network structure with hydrophilic materials. The tissue repair scaffold is used for meningeal repair, meninge repair, tissue engineering scaffold material, artificial skin, wound auxiliary material, biofilm, wound covering material, hemostatic material, postoperative anti-adhesion material or cosmetic material.

Description

technical field [0001] The invention relates to a medical device and its preparation, in particular to a tissue repair bracket and its preparation method and application. Background technique [0002] Tissue repair scaffolds are very common in clinical work, such as tendon repair, ligament repair, hernia repair, dura mater repair, female pelvic floor dysfunction disease repair, blood vessel repair, sling repair, skin repair, fistula repair , Nerve conduit repair, bone defect repair. [0003] Due to the defects of the existing materials and their pore structures, they are very different from the constituent units of human tissue, especially the hydrophobic synthetic materials adopt the general preparation method, and there is basically no good porous material similar to the extracellular matrix. It is difficult to conform to the characteristics of the anatomical structure of the tissue, and it is difficult to form good tissue compliance and adhesion with the anatomical struc...

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Problems solved by technology

[0003] Due to the defects of the existing materials and their pore structures, they are very different from the constituent units of human tissue, especially the hydrophobic synthetic materials adopt the general preparation method, and there is basically no good porous material similar to the extracellular matrix. structure, it is difficult to conform to the characteristics of tissue anatomy, and it is difficult to form good tissue compliance and adhesion with tissue anatomy

[0004] Woven mesh is currently the most widely used product in fiber membranes for tissue repair, but this type of product often has the following problems: 1) rough surface, hard texture, and poor tissue compliance. The friction of tissues gives patients a great degree of discomfort, which is prone to foreign body sensation and pain, causing common erosion and infection and other complications; 2) poor biocompatibility, and the immune rejection caused by such materials is strong, there are There are many sequelae of surgery; when it comes into direct contact with internal organs and organs, it is easy to cause damage, which can cause serious adhesions, severe foreign bodies and immune reactions, and requires a second operation to remove it, which brings pain to the patient and even threatens life

The current electrospun membranes are often found to be difficult or slow for cells to grow into the interior

The performance of fiber membranes for tissue repair formed by existing weaving and electrospinning technologies is not ideal

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