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Hydrogel pressure sealant system

A technology of hydrogel and therapeutic agent, applied in the field of hydrogel pressure sealant system, which can solve the problems of pneumothorax

Inactive Publication Date: 2016-02-17
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this biopsy or aspiration procedure still carries the risk of pneumothorax because of the difference between the patient and the health care provider performing the procedure

Method used

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Examples

Experimental program
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Effect test

example 1

[0094] Example 1: DCH and Gelatin Hydrogels with Lidocaine

[0095] Lidocaine-containing amphiphilic diblock copolypeptide hydrogels (DCH) were fabricated using different concentrations of K180L20 and compared with hydrogels fabricated with gelatin. These gels were formulated using saline buffer. Figure 7 Three compositions depicting hydrogels: left: 3% K180L20 + 1% lidocaine (99.7pa); middle: 4% K180L20 + 1% lidocaine (170.7pa); right: 10% gelatin + 1% Lidocaine (233Pa). In vitro and in vivo experiments with hydrogel compositions were performed to determine the optimal composition to provide the desired level of stiffness, tissue adhesion, pressure, sealing ability and lidocaine release rate for lung needle biopsy.

example 2

[0096] Example 2: HA Hydrogel

[0097] Hyaluronic acid (HA)-based hydrogels have demonstrated in vivo use in the past and are FDA-approved for various applications. Three concentrations of HA-based hydrogels were prepared for injection, 3% (w / v), 4% (w / v), and 5% (w / v), by mixing an appropriate amount of HA with saline buffer. The HA gel achieves the chosen stiffness. However, the presence of chemical linkages within the gel does not allow injection of the gel through a coaxial needle. HA gels tend to remain cohesive and collect in tubes ( Figure 8 ).

example 3

[0098] Example 3: Hydrogel Stiffness

[0099] The hydrogels of the present invention are required to have an optimal stiffness to allow the operator / interventionist to inject without encountering significant resistance, and the ability to stay in place without significantly spreading out from the target area. To test for proper stiffness, DCH at concentrations of 1% (w / v), 3% (w / v) and 4% (w / v) and 6% (w / v) and 10% (weight / volume) gelatin at various concentrations to subjectively determine the approximate range of available gel stiffness. Concentrations of 1% to 4% were injected without significant resistance. Higher resistance was felt at 6% and 10% concentrations and was difficult to use in clinical practice. DCH was then injected ex vivo into the fascial plane between chicken breast muscle and skin. 1% DCH exhibited rapid dispersion, while 3% and higher concentrations of DCH remained in place moderately ( Figure 9 ). From these experiments, it was concluded that 3% ...

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Abstract

The present invention includes devices, systems, and methods for sealing a defect in body tissue. For example, the present invention includes a device for preventing leakage of air and other gases from the lung during and after lung biopsy. The device delivers a hydrogel composition which forms an air-tight sealant. In certain embodiments, the device simultaneously delivers one or more therapeutic agents, such as lidocaine, to the treatment area.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application No. 61 / 831,375, filed June 5, 2013, which is hereby incorporated by reference in its entirety. Background of the invention [0003] Percutaneous needle lung biopsy (a biopsy performed through the chest wall) carries the risk of causing the patient to develop a pneumothorax or collapsed lung. Various studies have shown a pneumothorax rate between 19% and 60% after pulmonary fine needle aspiration (Poe et al., 1984, Chest, 85:232-235; Johnsrude et al., 1985, AJRAmJRoentgenol, 144: 793-794; Khouri et al., 1985, AJRAmJRoentgenol, 144:281-288; van Sonnenberg et al., 1988, Radiology, 167:457-461; Miller et al., 1988, Chest, 93:742-745; Fish et al., 1988, AJRAmJRoentgenol, 150:71-74; Hill et al., 1993, Chest, 104:1017-1020; Saji et al., 2002, Chest, 121:1521-1526). [0004] Lung collapse occurs when air leaks from the lungs into the space around them, preventing t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/145A61M5/19A61B17/03A61L24/08
CPCA61M5/19A61L24/08A61L24/0015A61L24/0031A61L2300/402A61B17/0057A61B2017/00495A61B2017/0065A61B2017/00654A61B2017/00893A61B17/00491C08L5/04A61M5/2448A61M5/284
Inventor 费雷敦·阿布蒂
Owner RGT UNIV OF CALIFORNIA
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