Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A method of using dopamine to quickly cross-link chitosan to prepare hemostatic sponge

A technology of cross-linked chitosan and hemostatic sponge, which is applied in medical science, absorbent pads, bandages, etc., and can solve problems such as cytotoxicity

Active Publication Date: 2018-05-01
深圳市和福汇生物科技有限公司
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of cross-linking agent has certain cytotoxicity, which makes it have certain limitations in the process of application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A method of using dopamine to quickly cross-link chitosan to prepare hemostatic sponge
  • A method of using dopamine to quickly cross-link chitosan to prepare hemostatic sponge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1) Weigh 5.00g chitosan hydrochloride (deacetylation degree is 85%) and dissolve it in 28mL deionized water, stir for 10min, a yellow viscous liquid appears; weigh 2g glycerin, dissolve it with 1mL deionized water; weigh Dissolve 1 g of poloxamer 407 in 20 mL of deionized aqueous solution, stir until completely dissolved, weigh 0.50 g of dopamine hydrochloride, and add it to the dissolved poloxamer 407 solution; 407 and dopamine hydrochloride solution were added to the chitosan hydrochloride solution and stirred for 20 min;

[0022] 2) Weigh 0.04g sodium periodate, dissolve it with 1mL deionized water and quickly add it to the foaming solution in step 1), and continue stirring for 15 minutes; pour the foaming solution obtained by stirring into a silica gel mold, and quickly transfer it to Freeze in a -30°C refrigerator for 24 hours; take the obtained sample out of the silica gel mold, transfer to a freeze dryer for freeze drying for 24 hours, and obtain a hemostatic spo...

Embodiment 2

[0024] Preparation of dopamine-crosslinked chitosan hemostatic cotton in Tris·HCl buffer solution: all the solvent water used in Example 1 was replaced by Tris·HCl buffer solution with pH=8.0, and other experimental conditions were the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing a hemostatic sponge by rapidly cross-linking chitosan with dopamine, which belongs to the field of biomedical materials. The present invention adopts dopamine to react with the amino group on the chitosan chain, and self-polymerization reaction occurs at the same time, so that the chitosan chain segments are cross-linked to form a cross-linked network structure, so that the obtained chitosan sponge has certain mechanical strength. And adding oxidizing agent sodium periodate in the reaction process accelerates the progress of the reaction and can greatly shorten the time for preparing the chitosan hemostatic cotton. The chitosan hemostatic sponge of the present invention has good biocompatibility, and has strong water absorption and swelling, mechanical properties, water-holding and moisturizing properties, biodegradability, good analgesic effect and hemostatic effect, and prevents wound infection Infection, promote the healing of injured tissue, is expected to be used in clinical emergency hemostasis.

Description

technical field [0001] The invention relates to a method for preparing a hemostatic sponge by rapidly cross-linking chitosan with dopamine, which belongs to the field of biomedical materials. Background technique [0002] If the bleeding caused by trauma is not stopped and bandaged in time, it will seriously threaten people's health and even life. Timely and effective hemostasis is very important for stabilizing the injury, saving the lives of the wounded, and creating conditions for follow-up treatment. [0003] Chitosan is a natural high molecular polymer, which belongs to amino polysaccharide. It is the only alkaline polysaccharide with cationic charge found so far. Chitosan can achieve the effect of hemostasis through the interaction between it and the red blood cell membrane, mainly the agglutination of red blood cells. However, the mechanical strength of pure chitosan sponge is poor, and the hemostatic effect is very limited, and the hemostatic effect is not good fo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/42
Inventor 徐福建胡浩罗旭
Owner 深圳市和福汇生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com