Refining and purification method of N-acylamino acid
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A kind of acyl amino acid, refining and purifying technology, applied in the field of refining and purifying N-acyl amino acid
Active Publication Date: 2016-02-24
JIUJIANG TINCI ADVANCED MATERIALS CO LTD
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Problems solved by technology
[0004] Aiming at the above problems, the present invention provides a new method for refining and purifying N-acyl amino acids, which can effectively solve the problem of poor purification effect, low efficiency, and easy-to-produce products in the prior art. Yellow and some products will form by-products with solvents, etc.
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Embodiment 1
[0023] A method for refining and purifying N-acyl amino acids, comprising the following steps:
[0024] (1) In a mixed solvent of ethanol and water (volume ratio 1:2), mix cocoyl chloride and sodium glutamate evenly, and conduct condensation reaction for 4.5 hours at a temperature of 21°C and a pH of 10;
[0025] (2) Raise the temperature of the feed liquid to 75°C, adjust the pH to 3, and carry out vacuum distillation to remove most of the ethanol;
[0026] (3) After cooling the feed liquid to 40°C, acidify it and adjust the pH to 2.5; then, cool down to 30°C to solidify the N-acyl amino acid in the feed liquid, and then form a dispersion liquid with water;
[0027] (4) Use a diaphragm filter press to remove the water in the dispersion, and then use normal temperature deionized water of the same quality as the material for dispersion washing ， After washing with water for 60 minutes, filter through a filter (at the same time, take a small amount of washed material and dry it...
Embodiment 2
[0031] A method for refining and purifying N-acyl amino acids, comprising the following steps:
[0032] (1) In a mixed solvent of ethanol and water (volume ratio 1:3), mix lauroyl chloride and sodium glycinate evenly, and conduct a condensation reaction at a temperature of 17°C and a pH of 14 for 5.0 hours;
[0033] (2) Raise the temperature of the feed liquid to 60°C, adjust the pH to 5, and carry out vacuum distillation to remove most of the ethanol;
[0034] (3) After cooling the feed liquid to 50°C, acidify it and adjust the pH to 0.5; then, cool down to 10°C to solidify the N-acyl amino acid in the feed liquid, and then form a dispersion liquid with water;
[0035] (4) Use a diaphragm filter press to remove the water in the dispersion, and then use normal temperature deionized water of the same quality as the material for dispersion washing ， After washing with water for 60 minutes, filter through a filter (at the same time, take a small amount of washed material and dry...
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Abstract
The invention belongs to the field of fine chemical industry, and particularly relates to a novel refining and purification method of N-acylamino acid. The method comprises the following steps that 1, the N-acylamino acid is synthesized through a conventional condensation reaction; 2, most of ethyl alcohol in liquid subjected to the condensation reaction is removed through vacuum distillation; 3, an organic phase is separated from a water phase through acidification, and by means of cooling, the N-acylamino acid and water are made to form dispersion liquid; 4, water in the dispersion liquid is removed through a diaphragm filter press, dispersing and washing are conducted through water of which the mass is equal to that of materials, filtration is conducted through a filter, dispersing and washing are repeatedly conducted in this way for 3-5 times, drying is conducted, and high-purity N-acylamino acid solid powder is obtained. According to the novel refining and purification method of the N-acylamino acid, the problems that in the prior art, the purification effect is poor, the efficiency is poor, products are prone to yellowing, and by-products can be produced through part products and solvent can be effectively solved.
Description
technical field [0001] The invention belongs to the field of fine chemical industry, and specifically relates to a new method for refining and purifying N-acyl amino acids. Background technique [0002] In recent years, amino acid series surfactants have attracted people's attention because of their safety, biodegradability and excellent surface activity. N-acyl amino acid is an anionic surfactant formed by condensation of lauric acid and cocoic acid with amino acids, and has been widely used in daily chemicals, such as cleansing cream, toothpaste and shaving cream. [0003] At present, the industrial production of N-acyl amino acids is through condensation reaction, acidification and liquid separation, and then neutralization to form salts. This method uses liquid separation and purification to purify N-acyl amino acids. The purification effect is poor, and the product contains a lot of impurities. Usually for To improve the purification effect, a second liquid separation ...
Claims
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Application Information
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