Content determination method for scutellarin and scutellarein in sculellaria barbata medicinal material and formula granule of sculellaria barbata medicinal material

A technology of scutellarein and scutellarein, which is applied in the field of content determination of scutellarein and scutellarein in Scutellaria barbata and its formula granules, which can solve the problems of not being searched and ensure accuracy and reproducibility Effect
CN105353053AActive Publication Date: 2016-02-24HEBEI UNIV OF CHINESE MEDICINE +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEBEI UNIV OF CHINESE MEDICINE
Publication Date
2016-02-24

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Abstract

The invention relates to a content determination method for scutellarin and scutellarein in sculellaria barbata medicinal material and formula granule of sculellaria barbata medicinal material. The content determination method is characterized in that common isocratic elution is adopted, acetonitrile-methyl alcohol-0.1 percent phosphoric acid of which the volume ratio is 12.5:(15 to 16.2):(71.3 to 72.5) is taken as a mobile phase, and the contents of the scutellarin and the scutellarein in the sculellaria barbata medicinal material and the formula granule of the sculellaria barbata medicinal material are simultaneously determined at a wavelength of 340+ / -2nm. The method is simple, convenient, fast, and easy to popularize and master; the separations of wave crests on three different chromatographic columns are good. Compared with a method of recording under a sculellaria barbata medicinal material item of the first part of the pharmacopeia, the prominent improvement is that a sample treatment process is simplified, the time and cost are saved, the determination is advanced from single component determination of the scutellarin to the simultaneous determination of the two components, the quality controllability is improved, and the defects that impurity peaks exist and the content results are inaccurate are overcome.
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Description

technical field

[0001] A method for determining the content of scutellarein and scutellarein in Scutellaria barbata medicinal material and its formula granules. Background technique

[0002] Scutellaria barbata is the dried whole herb of Lamiaceae plant Scutellaria barbata D.Don. It is a commonly used traditional Chinese medicine, which has the effects of clearing heat and detoxifying, removing blood stasis and diuresis. For furuncle swelling, sore throat, tumbling pain, edema, jaundice, snake and insect bites. It mainly contains flavonoids, such as baicalein, wogonin, apigenin, luteolin, naringenin, scutellarin, 7-hydroxy-5,8 dimethoxyflavone, 7-hydroxy-5,8 dimethoxy Methoxyflavone-7-O-β-D-glucoside, 5, 7, 8, 2-tetrahydroxyflavone-7-O-β-D-glucoside, etc., also contains some diterpene and triterpene lactones class etc. Its quality standard does not include the TLC identification item under the Chinese Pharmacopoeia 2015 edition of a section of Scutellaria barbata medicin...

Claims

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