Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling

A non-invasive, speckle image technology, applied in the direction of using light for diagnosis, calculation, image analysis, etc., can solve the problem that fluorescence imaging cannot provide information

Inactive Publication Date: 2016-02-24
EAST CAROLINA UNIVERISTY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, fluorescence imaging is often not informative to directly determine the velocity of blood flow in the main vessel

Method used

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  • Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling
  • Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling
  • Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling

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Embodiment Construction

[0104] Embodiments of the inventive concept will now be described more fully below with reference to the accompanying drawings, in which preferred embodiments of the inventive concept are shown. However, the inventive concepts may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Like reference numerals refer to like elements throughout. In the drawings, layers, regions, elements or components may be exaggerated for clarity. Dashed line drawings illustrate optional features or operations unless specified otherwise.

[0105] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the inventive concepts. As used herein, the singular forms "a", "an" and "the" are intended to also be in the plural unless the context clearly dictates otherwise. It will also be understood that when used in this specification, the terms "comprising" and / or "comprisin...

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Abstract

Non-invasive methods for determining blood flow distribution in a region of interest are provided. The method includes illuminating a region of interest of a subject with a coherent light source; sequentially acquiring at least two speckle images of the region of interest, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject; and electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image, determine distribution of blood flow speed in principal vessels and quantify perfusion distribution in tissue in the region of interest from the LSCI image. The LSCI image enables detection of different blood flow speeds.

Description

[0001] priority claim [0002] This application claims priority from U.S. Application No. 13 / 819,817, filed Feb. 28, 2013, which is a U.S. national phase application of PCT / US2012 / 020626, filed Jan. 9, 2012, which claims Jan. 10, 2011 Priority to U.S. Provisional Application No. 61 / 431,161, filed April 19, 2011, and U.S. Provisional Application No. 61 / 476,854, filed April 19, 2011, the disclosures of which are hereby incorporated by reference herein as if set forth in their entirety. [0003] copyright reserved [0004] The disclosed portion of this patent document contains material that is subject to copyright protection. Copyright owner East Carolina University, Greenville, NC has no objection to anyone's reproduction of this patent document or the patent disclosure as it appears in the Patent and Trademark Office patent file or records, but otherwise reserves all rights reserved. copyright rights. technical field [0005] The inventive concept relates generally to blood ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/026A61B5/0402
CPCA61B5/0059A61B5/02007G02B27/48A61B5/0044A61B5/0066A61B5/0077A61B5/0261A61B5/318G06T7/0012
Inventor T.B.小费尔古森胡新华陈成
Owner EAST CAROLINA UNIVERISTY
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