Combination of active agents for oral administration for improving the quality of nails
A technology of active agents and nails, which is applied to the combination of active agents, and proposes the field of combination of active agents, which can solve problems such as excessive cross-linking bonds and nail embrittlement.
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Embodiment 1
[0116] To characterize the relationship of brittle / split nails to prehypertensive status relative to normal nails
[0117] Seventy healthy females ranging in age from 18 to 50 years were included in the study presented in the remainder of this article. Of these 70 women, 35 had brittle / split nails and 35 had normal nails.
[0118] The nature of nail brittleness was confirmed by clinical assessment using a grade scale previously published by van de Kerkhof PC, Pasch MC, Scher RK, Kerscher M, Gieler U, Haneke E, Fleckman P. Brittle nail syndrome: apathogenesis-based approach with a proposed grading system. J .Am.Acad.Dermatol.2005 Oct;53(4):644-51.), the grade scale will test the nail for onycholysis (transversal and lamellar splits) and brittle onychomycosis (striation and longitudinal fractures ) into account. These evaluations were performed on the most severely damaged nail on one of the two hands selected by the clinician.
[0119] During the course of this study, arteri...
Embodiment 2
[0124] Demonstration of the inhibitory effect of the combination of active agents according to the invention on the basal synthesis / release of MMP-9 from human epidermal keratinocytes
[0125] Many cell types are capable of producing MMP-9: endothelial cells, immune cells, junctional cells and keratinocytes.
[0126] Human skin keratinocytes were chosen as an experimental model for in vitro evaluation due to their high availability and their ease of use, as well as their similarity to endothelial cells to the extent that they contribute to epithelial cell formation sex.
[0127] In particular, hair endothelial cells are more difficult to obtain. Similarly, the high sensitivity to proteases of endothelial cells compared to cultured keratinocytes precludes simple and reproducible testing of the effects of these modulators of MMP-9. This is inter alia due to the growth inhibitory effect of these cells on the degradation product produced by most MMP-9 (angiostatin) (Brauer et al...
Embodiment 3
[0145] Oral compositions in the form of soft capsules
[0146]
[0147] When the composition is orally administered to an individual at a rate of two flake capsules per day, an improvement in the quality of the nail and the general aesthetic appearance of the nail can be observed in the individual.
[0148] These effects were more pronounced when the tested individual was prehypertensive, ie before the test, his nails were of poor quality and had an average or even poor general aesthetic appearance.
[0149] The combination of active agents according to the invention allows for a better supply of nutrients through the blood to these microvascular cells, thus protecting them from attacks associated with MMP-9 activity and thus allowing for a better quality of the nail and the surrounding skin and better general aesthetic appearance.
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