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Use of niclosamide phosphate for preparing medicine for inhibiting renal tissue fibrosis

A technology of nisalamide phosphate and tissue fibrosis, which can be applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve problems such as lack of renal fibrosis

Inactive Publication Date: 2018-08-17
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still no effective drug for the treatment of renal fibrosis in clinical practice.

Method used

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  • Use of niclosamide phosphate for preparing medicine for inhibiting renal tissue fibrosis
  • Use of niclosamide phosphate for preparing medicine for inhibiting renal tissue fibrosis
  • Use of niclosamide phosphate for preparing medicine for inhibiting renal tissue fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Inhibition experiment of niclosamide phosphate (p-NICLO) on renal fibrosis in UUO mice

[0030] 1. Experimental animals: BALB / c mice, male, weighing 23-25g, SPF grade. The animals were first weighed and numbered, and 15 healthy mice weighing 23-25 ​​g were selected and randomly divided into 3 groups with 5 mice in each group. Including sham operation group, positive control group and medication group.

[0031] 2. Treatment of each group

[0032] (1) Sham operation group: at room temperature, after anesthetized with 0.05ml / 10g of 1.5% pentobarbital sodium, choose the incision 1-2cm below the left dorsal costal margin; after local disinfection, cut the skin, subcutaneous, muscle Layers and peritoneum were found, and the left ureter was sutured layer by layer. After local disinfection, check the marks and place them in corresponding mouse cages.

[0033] (2) Positive control group: Same as above for anesthesia and disinfection. The skin, subcutaneous layer,...

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Abstract

The invention relates to new application of niclosamide phosphate to preparation of medicine for inhibiting kidney tissue fibrosis. The invention provides niclosamide phosphate as shown in formula I and application thereof to preparation of medicine for inhibiting kidney tissue fibrosis. The niclosamide phosphate is good in inhibiting effect on the kidney tissue fibrosis and free of fatal side effects. The niclosamide phosphate can be prepared into preparations such as orally-taken preparations or injection for inhibiting the kidney tissue fibrosis.

Description

technical field [0001] The invention relates to a new application of niclosamide phosphate, a derivative of niclosamide (English name Niclosamide), which has been clinically used for many years. Background technique [0002] The incidence of adult chronic kidney disease (CKD) is as high as 11-13%, and almost all chronic kidney diseases progress to end-stage renal disease (ESRD). There are few good treatments for ESRD except for renal replacement therapy. And "kidney replacement therapy" consumes a lot of health resources every year, and is called "the most expensive disease". Renal tissue fibrosis is a common path for almost all chronic kidney diseases to progress to ESRD, and is the main pathological manifestation of various chronic kidney diseases. Inhibiting renal tissue fibrosis can effectively delay the progression of chronic kidney disease, prolong the time when chronic kidney disease progresses to ESRD and requires renal replacement therapy, thereby greatly saving h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/661A61P13/12
CPCA61K31/661
Inventor 聂静丁克常晓燕朱风新
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV