Supercharge Your Innovation With Domain-Expert AI Agents!

Medical application of salvianolic acid B sophocarpidine salt in protecting from inflammations caused by TNF-alpha or IL6

A technology for salvianolic acid and matrine, which is applied in the field of protecting inflammation caused by TNF-α or IL6, in the field of salvianolic acid B matrine sodium double salt and salvianolic acid B matrine sodium double salt. Solve problems such as unstable physical properties

Inactive Publication Date: 2016-03-30
于非
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the physical properties of the two compounds are very unstable, with strong hygroscopicity, and matrine is easily oxidized

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical application of salvianolic acid B sophocarpidine salt in protecting from inflammations caused by TNF-alpha or IL6
  • Medical application of salvianolic acid B sophocarpidine salt in protecting from inflammations caused by TNF-alpha or IL6
  • Medical application of salvianolic acid B sophocarpidine salt in protecting from inflammations caused by TNF-alpha or IL6

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1 Salvianolic acid B matrine salt improves liver fibrosis in mice caused by inflammation caused by TNF-α or IL6

[0070] 1.1 Experimental animal models

[0071] Except for the blank control group, the other mice were injected with 0.05ml / 10g body weight of 4% CCl4 vegetable oil solution twice a week for 6 weeks (tissue sections showed that the model was established effectively). The blank control group was intraperitoneally injected with vegetable oil solution at 0.05ml / 10g.

[0072] 1.2 Grouping and handling of animals

[0073] The mice that successfully established the model were randomly divided into 7 groups according to body weight. They are the model group, the compound Biejia Ruangan tablet positive control group, the salvianolic acid B matrine compound salt low, medium and high dose groups, the salvianolic acid B control group, and the matrine control group. Three weeks after modeling, each group began to administer the drug according to the dose set ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medical application of a salvianolic acid B sophocarpidine salt, a salvianolic acid B kurarinonesalt, a salvianolic acid B sophocarpidine sodium double salt and a salvianolic acid B kushenin sodium double salt in protecting from inflammations caused by TNF-alpha or IL6. The salvianolic acid B sophocarpidine double salt is expected to be used for treating the diseases caused by the abnormity of TNF-alpha or IL6.

Description

technical field [0001] The present invention relates to salvianolic acid B matrine salt and salvianolic acid B matrine salt, and single sodium double salt thereof, salvianolic acid B matrine sodium double salt and salvianolic acid B matrine sodium double salt, Application in protecting inflammation caused by TNF-α or IL6. Background technique [0002] Salvianolic acid B is one of the main active ingredients of Salvia miltiorrhiza, Xinjiang sage and other sage plants. There are two carboxyl-containing danshenin fragments in the molecule. Studies have shown that salvianolic acid B has good pharmacological effects in anti-hypoxia, anti-cardiocerebral ischemia, treatment of coronary heart disease, liver injury, and liver fibrosis. Salvianolic acid B (salvianolic acid) is widely used clinically in the treatment of liver fibrosis. However, salvianolic acid B molecules are difficult to pass through the lipid membrane of intestinal epithelial cells due to their strong hydrophilici...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4375A61P29/00A61P1/16A61P11/00A61P11/06A61P13/12A61P9/00A61P9/10A61K31/343
CPCA61K31/4375A61K31/343A61K2300/00
Inventor 于非王金辉魏秀岩卢立娜
Owner 于非
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com