The method and application of a liquid -phase synthetic polypeptide
A liquid-phase synthesis and solution technology, which is applied in the fields of organic synthesis and pharmaceutical preparation, can solve problems such as huge environmental hazards, achieve the effects of simplified synthesis process, mild reaction conditions, and high reaction flexibility
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Embodiment 1
[0039] Prepare a 0.0005mol / L phenylalanine aqueous solution, put the prepared solution into a cold plasma discharger, place it between the two electrode plates of the plasma, seal it, evacuate the vacuum chamber, and then fill it with argon As a discharge gas, maintain a pressure of 200Pa, apply an AC voltage of 300V to the electrode, use glow discharge plasma, and induce a reaction under stirring conditions, and the reaction time is 6 minutes. The plasma action process was repeated 5 times, and the volatilized solvent in the reaction process was replenished before each treatment, and the solution after the reaction was separated by high performance liquid chromatography to obtain phenylalanine tetrapeptide. The reaction process does not use a condensing agent, does not need to separate and recycle the condensing agent, and is environmentally friendly.
[0040] The mass spectrometric analysis of the obtained samples, such as figure 2 . A chemical species with a molecular weig...
Embodiment 2
[0042] Prepare a 0.1mol / L glycine ethanol solution, add copper chloride as a catalyst, the concentration of copper chloride is 0.01mol / L, put the prepared solution into a cold plasma discharger, and place it between the two electrode plates of the plasma The room is airtight, the vacuum chamber is evacuated, and then filled with argon as the discharge gas to maintain a pressure of 100Pa, and an AC voltage of 200V is applied to the electrode, using glow discharge plasma, the plasma temperature is 20 ° C, under stirring conditions , the induced reaction takes place. The temperature at the contact point between the solution and the plasma was 10° C., and the reaction time was 10 minutes. The plasma action process was repeated 6 times, the solvent volatilized in the reaction process was replenished before each treatment, and the solution after the reaction was separated by high performance liquid chromatography to obtain glycine octapeptide. The reaction process does not use a co...
Embodiment 3
[0045] Prepare a 0.005mol / L alanine methanol solution, put the prepared solution into a cold plasma discharger, place it between the two electrode plates of the plasma, seal it, evacuate the vacuum chamber, and then fill it with argon As discharge gas, maintain a pressure of 250Pa, apply an AC voltage of 600V on the electrode, use glow discharge plasma, and the plasma temperature is 60°C. Under stirring conditions, the induced reaction occurs, and the reaction time is 8min. The plasma action process was repeated 4 times, the volatilized solvent in the reaction process was replenished before each treatment, and the solution after the reaction was separated by high performance liquid chromatography to obtain the alanine octapeptide. The reaction process does not use a condensing agent, does not need to separate and recycle the condensing agent, and is environmentally friendly.
[0046] The mass spectrometric analysis of the obtained samples, such as Figure 4 . A chemical spec...
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