Connecting method for novel mixed bioartificial liver system

Abstract

The invention discloses a connecting method for a novel mixed bioartificial liver system. The novel mixed bioartificial liver system comprises blood treatment equipment with an input end, an output end and a plasma dividing end, a bioreactor with an upper end opening and a lower end opening opposite to the upper end opening, and a circulating tube for enabling the blood treatment equipment and the bioreactor to be communicated and connected. The upper end opening and the lower end opening are used for pouring a culture medium. Connecting of the circulating tube comprises the steps of mounting and exhausting, and according to the connecting sequence of the circulating tube, an artery tube communicated with the input end of the blood treatment equipment is connected, a vein tube communicated with the output end of the blood treatment equipment is connected, a plasma dividing tube between the plasma dividing end of the blood treatment equipment and the bioreactor is connected, a reactor tube of the bioreactor is connected, and a plasma return tube between the bioreactor and the vein tube is connected. The connecting method is easy and convenient to operate, the sealing performance among the tubes is good, and clinical application is facilitated.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a connection method of a novel hybrid bioartificial liver system. Background technique [0002] Acute liver failure is often caused by viral hepatitis, drug poisoning, toxic substance poisoning and autoimmunity. For patients with severe hepatitis and liver failure, the current treatment methods are mainly medical treatment and liver transplantation, but the effect of drug treatment is not ideal; the most effective clinical treatment is liver transplantation, but liver transplantation is limited due to the shortage of liver donors Wide application; artificial liver support system has brought a new dawn for patients with liver failure. [0003] At present, the treatment of artificial liver is mostly non-biological artificial liver, and its treatment modes mainly include plasma exchange and hemoperfusion adsorption, etc., which cannot meet the needs of patients; hybrid bioartificial ...

AI Technical Summary

Problems solved by technology

For patients with severe hepatitis and liver failure, the current treatment methods are mainly medical treatment and liver transplantation, but the effect of drug treatment is not ideal; the most effective clinical treatment is liver transplantation, but liver transplantation is limited due to the shortage of liver donors Widespread application; artificial liver support system brings new light to patients with liver failure

[0003] At present, most of the artificial liver treatments are non-bioartificial livers. The treatment modes mainly include plasma exchange and hemoperfusion adsorption, etc., which cannot meet the needs of patients; hybrid bioartificial livers can better meet the treatment needs of patients, but Since the hybrid bioartificial liver has many treatment modes and complex pipelines, how to design a simple and easy-to-understand operation method to reduce the risk of pipeline connection prefilling, operation errors in parameter setting, and pipeline contamination is currently an issue. One of the urgent problems

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