A method for rapidly preparing an anti-infection functional dressing

Abstract

The invention discloses a method for fast preparing an anti-infection dressing. The method includes the steps of firstly, preparing functional coating liquid; secondly, soaking non-woven fabric, fabric or a thin film with the functional coating liquid or spraying the functional coating liquid to the non-woven fabric, the fabric or the thin film, and drying; thirdly, washing the dried medical non-woven fabric, fabric or thin film soaked or sprayed with the functional coating liquid, and drying to obtain the anti-infection dressing. The anti-infection dressing can overcome the defects in the prior art and is lasting in anti-infection function and good in biocompatibility, the coating does not fall off easily, and the anti-infection rate of the anti-infection dressing reaches more than 90%.

Description

technical field

[0001] The invention relates to a method for rapidly preparing a dressing with anti-infection function. Background technique

[0002] As a covering for the wound, wound dressing can replace the damaged skin to act as a temporary barrier during the wound healing process, avoid or control external stimuli, and provide a microenvironment conducive to wound healing. With the aging population and the increase of chronic ulcerative wounds, the market value of medical dressings is also becoming more and more important. In addition to tissue damage and the patient's physical fitness, the most important factor affecting wound healing is bacterial infection of the wound, which leads to chronic ulcers and inflammation of the wound. Bacteriological culture and drug susceptibility testing were carried out on non-healing wound secretion samples from trauma patients in Tianjin Hospital. The results showed that 2396 strains of pathogenic bacteria were isolated from 35-45 c...

Examples

Embodiment 1

[0027] Measure 1000ml of Tris-HCl buffer solution with a pH value of 7.5, weigh 5000mg of dopamine and dissolve it in the buffer solution. Then, 10 mg of polyhexamethylene biguanide hydrochloride was weighed and added into the solution to fully dissolve it, and the pH value was adjusted to 7.5 with NaOH solution to form a functional coating liquid. Soak the polyethylene non-woven fabric in the functional coating solution. After fully soaking, take out the polyethylene non-woven fabric and place it in a natural environment with a temperature of 25°C to dry. After fully drying, place the polyethylene non-woven fabric on the The dressings were ultrasonically washed three times in deionized water and ethanol liquid respectively, and after drying, the corresponding anti-sensitivity functional dressings were obtained.

[0028] figure 1 It is the physical picture of the anti-infection functional dressing prepared in Example 1. The anti-sensitivity functional dressing that embodimen...

Embodiment 2

[0030] Measure 1000ml of Tris-HCl buffer solution with a pH value of 9.5, weigh 50mg of dopamine and dissolve in the buffer solution. Then weigh 10 mg of polyhexamethylene biguanide hydrochloride and 5 mg of silver nitrate and add them into the solution to make them fully dissolved, and adjust the pH value to 9.5 with NaOH solution to form a functional coating liquid. Soak the ethylene terephthalate non-woven fabric in the functional coating solution. After fully soaking, take out the ethylene terephthalate non-woven fabric and place it in a natural environment at a temperature of 25°C to dry. After drying, the ethylene terephthalate non-woven fabric was placed in deionized water and ethanol liquid and ultrasonically washed three times respectively, and after drying, a corresponding anti-infection functional dressing was obtained.

[0031] The anti-sensitivity functional dressing that embodiment 2 makes is 1 * 10 to concentration. 5 The antibacterial rates of Escherichia coli...

Embodiment 3

[0033] Measure 1000ml of phosphate buffer solution with a pH value of 8.5, weigh 1000mg of dopamine and dissolve in the buffer solution. Then weigh 50000 mg of quaternary ammonium antibacterial agent (methacryloyloxydodecylpyridinium bromide) and add it into the solution to make it fully dissolved, and adjust the pH value to 8.5 with NaOH solution to form a functional coating liquid. Soak the cellulose fabric in the functional coating solution. After fully soaking, take out the cellulose fabric and place it in a natural environment with a temperature of 25°C to dry. After fully drying, place the cellulose fabric in deionized water and ethanol liquid Each was ultrasonically washed 3 times, and after drying, the corresponding anti-sensitivity functional dressings were obtained.

[0034] The anti-sensitivity functional dressing that embodiment 3 makes is 1 * 10 to concentration. 5 The antibacterial rates of Escherichia coli, Staphylococcus aureus and Candida albicans in CFU / ml w...

technical field

[0001] The invention relates to a method for rapidly preparing a dressing with anti-infection function. Background technique

[0002] As a covering for the wound, wound dressing can replace the damaged skin to act as a temporary barrier during the wound healing process, avoid or control external stimuli, and provide a microenvironment conducive to wound healing. With the aging population and the increase of chronic ulcerative wounds, the market value of medical dressings is also becoming more and more important. In addition to tissue damage and the patient's physical fitness, the most important factor affecting wound healing is bacterial infection of the wound, which leads to chronic ulcers and inflammation of the wound. Bacteriological culture and drug susceptibility testing were carried out on non-healing wound secretion samples from trauma patients in Tianjin Hospital. The results showed that 2396 strains of pathogenic bacteria were isolated from 35-45 c...

Examples

Embodiment 1

[0027] Measure 1000ml of Tris-HCl buffer solution with a pH value of 7.5, weigh 5000mg of dopamine and dissolve it in the buffer solution. Then, 10 mg of polyhexamethylene biguanide hydrochloride was weighed and added into the solution to fully dissolve it, and the pH value was adjusted to 7.5 with NaOH solution to form a functional coating liquid. Soak the polyethylene non-woven fabric in the functional coating solution. After fully soaking, take out the polyethylene non-woven fabric and place it in a natural environment with a temperature of 25°C to dry. After fully drying, place the polyethylene non-woven fabric on the The dressings were ultrasonically washed three times in deionized water and ethanol liquid respectively, and after drying, the corresponding anti-sensitivity functional dressings were obtained.

[0028] figure 1 It is the physical picture of the anti-infection functional dressing prepared in Example 1. The anti-sensitivity functional dressing that embodimen...

Embodiment 2

[0030] Measure 1000ml of Tris-HCl buffer solution with a pH value of 9.5, weigh 50mg of dopamine and dissolve in the buffer solution. Then weigh 10 mg of polyhexamethylene biguanide hydrochloride and 5 mg of silver nitrate and add them into the solution to make them fully dissolved, and adjust the pH value to 9.5 with NaOH solution to form a functional coating liquid. Soak the ethylene terephthalate non-woven fabric in the functional coating solution. After fully soaking, take out the ethylene terephthalate non-woven fabric and place it in a natural environment at a temperature of 25°C to dry. After drying, the ethylene terephthalate non-woven fabric was placed in deionized water and ethanol liquid and ultrasonically washed three times respectively, and after drying, a corresponding anti-infection functional dressing was obtained.

[0031] The anti-sensitivity functional dressing that embodiment 2 makes is 1 * 10 to concentration. 5 The antibacterial rates of Escherichia coli...

Embodiment 3

[0033] Measure 1000ml of phosphate buffer solution with a pH value of 8.5, weigh 1000mg of dopamine and dissolve in the buffer solution. Then weigh 50000 mg of quaternary ammonium antibacterial agent (methacryloyloxydodecylpyridinium bromide) and add it into the solution to make it fully dissolved, and adjust the pH value to 8.5 with NaOH solution to form a functional coating liquid. Soak the cellulose fabric in the functional coating solution. After fully soaking, take out the cellulose fabric and place it in a natural environment with a temperature of 25°C to dry. After fully drying, place the cellulose fabric in deionized water and ethanol liquid Each was ultrasonically washed 3 times, and after drying, the corresponding anti-sensitivity functional dressings were obtained.

[0034] The anti-sensitivity functional dressing that embodiment 3 makes is 1 * 10 to concentration. 5 The antibacterial rates of Escherichia coli, Staphylococcus aureus and Candida albicans in CFU / ml w...

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