A kind of preparation method of compound corydalis corydalis varnish for local analgesia

A technology of Corydalis and film coating agent, applied in the directions of non-central analgesics, medical preparations without active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor water resistance, insufficient mechanical strength and toughness, and film forming time Long and other problems, to achieve the effect of good therapeutic effect, good mechanical properties, and short film forming time

Active Publication Date: 2017-10-13
HARBIN KANGLONG PHARM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to enrich the dosage forms of Corydalis Corydalis and solve the problems of poor water resistance, insufficient mechanical strength and toughness, and long film-forming time in the prior art, one of the purposes of the present invention is to provide a compound Corydalis Corydalis film-coating agent for local analgesia

Method used

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  • A kind of preparation method of compound corydalis corydalis varnish for local analgesia
  • A kind of preparation method of compound corydalis corydalis varnish for local analgesia
  • A kind of preparation method of compound corydalis corydalis varnish for local analgesia

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Embodiment 1

[0043] A kind of local analgesic compound corydalis corydalis varnish, by weight, it is made of the following raw materials and pharmaceutically acceptable adjuvants: wherein, said raw material comprises 4 parts of corydalis, 4 parts of Wulingzhi, bletilla striata 7 parts; the pharmaceutically acceptable auxiliary material comprises 13 parts of the combination of PVA124 and polyvinyl formal (weight ratio is 1:0.1), 18 parts of absolute ethanol, and 8 parts of glycerin.

[0044] The method for preparing above-mentioned film-coating agent, this method comprises steps as follows:

[0045] 1) Processing of APIs:

[0046] ① Weigh Corydalis Corydalis in parts by weight of the formula, place it in a mixed solution consisting of ethanol aqueous solution, acetic acid aqueous solution and gallic acid in a weight ratio of 1:0.5:0.01 with a solid-to-liquid ratio of 1:3, and place it at 30°C Ultrasonic treatment for 6 hours under the same conditions, drained and belt-type vacuum-dried at ...

Embodiment 2

[0058] A compound Corydalis Corydalis varnish for local pain relief, which is made of the following raw materials and pharmaceutically acceptable adjuvants in parts by weight: wherein, the raw materials include 10 parts of Corydalis Corydalis, 1 part of Wulingzhi, Bletilla striata 7 parts; The pharmaceutically acceptable adjuvant comprises 10 parts of epichlorohydrin modified PVA124 and zein (4:1 by weight), 10 parts of dehydrated alcohol, 5 parts of propylene glycol,

[0059] Among them, the process conditions of epichlorohydrin modified PVA124 are: the solvent is dimethyl sulfoxide, the etherification agent is epichlorohydrin, the molar ratio of epichlorohydrin to polyvinyl alcohol is 1.5:1.0, and the etherification temperature The temperature is 65°C, and the reaction time is 6 hours. For details, please refer to "Etherification Modification of Polyvinyl Alcohol and Analysis of Influencing Factors" (Kang Yong et al., "Shanghai Plastics", Issue 4, 2015, P45-48).

[0060] The...

Embodiment 3

[0073] A compound Corydalis Corydalis varnish for local pain relief, which is made of the following raw materials and pharmaceutically acceptable adjuvants in parts by weight: wherein, the raw materials include 1 part of Corydalis Corydalis, 10 parts of Wulingzhi, Bletilla striata 30 parts; the pharmaceutically acceptable excipients include 20 parts of PVA124 and chitin (5:1 by weight), 5 parts of ethyl acetate, 13 parts of anhydrous methanol, 4 parts of sorbitol, and 4 parts of mannitol.

[0074] The preparation method of this coating agent is with embodiment 1.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a preparation method of a compound rhizoma corydalis film coating agent for local pain relieving. The preparation method comprises the following steps of 1 raw material medicine processing, 2 supercritical carbon dioxide extracting and 3 film coating agent preparing. The compound rhizoma corydalis film coating agent for local pain relieving is prepared from the following raw material medicines and pharmaceutically acceptable auxiliary materials, wherein the raw material medicines comprise, by weight, 1-10 parts of rhizoma corydalis, 1-10 parts of trogopterus dung and 1-30 parts of common bletilla tubers, and the pharmaceutically acceptable auxiliary materials comprise, by weight, 2-20 parts of a film forming material, 3-18 parts of volatile organic solvent and 2-8 parts of a plasticizer. According to the preparation method of the compound rhizoma corydalis film coating agent for local pain relieving, the dissolution efficiency of the effective constituents is high, and destruction to the effective constituents is little; the prepared film coating agent is short in film forming time, does not has the skin irritation, has the anti-inflammatory action and has the better treatment effect on diseases such as rheumatism ostealgia prone to relapse.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a preparation method of a compound corydalis corydalis film-coating agent for local analgesia. Background technique [0002] Corydalis Corydalis is the dry tuber of Corydalis Corydalis, a common analgesic drug, which was praised by the predecessors as "specially treating all kinds of pain in one body". Corydalis Corydalis is pungent in taste, bitter, warm in nature; returns to liver and spleen meridian; has the effects of promoting blood circulation, promoting qi circulation and relieving pain. Regardless of headache, chest and abdominal pain, hypochondriac pain, menstrual pain, arthralgia, bruise pain, which is caused by stagnation of Qi and blood, it can be used for pure pain. The effect is quick but not dry, and the pain relief effect is good. Clinically, it is mostly used to treat gynecological dysmenorrhea. It is combined with C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61K9/70A61K47/32A61P29/00A61P19/08A61K35/24
CPCA61K9/0014A61K9/7015A61K35/24A61K36/66A61K36/898A61K47/32A61K2236/17A61K2236/333A61K2236/37A61K2300/00
Inventor 穆滨郑东友吴琳华杨波何林
Owner HARBIN KANGLONG PHARM CO LTD
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