Water pressure-based control system for subnanoscale single-cell motion

A single-cell motion, sub-nanometer technology, applied in the method of biological material sampling, bioreactors/fermenters for specific purposes, biochemical instruments, etc. Platform space, high control accuracy, and minimal damage to living cells

Inactive Publication Date: 2017-07-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few formed single-cell motion control systems on the market, especially as sub-modules, single-cell motion control systems that can be easily and conveniently integrated into new systems are even rarer

Method used

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  • Water pressure-based control system for subnanoscale single-cell motion
  • Water pressure-based control system for subnanoscale single-cell motion
  • Water pressure-based control system for subnanoscale single-cell motion

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Embodiment Construction

[0032] The present invention will be further described below in conjunction with drawings and embodiments.

[0033] Such as figure 1 As shown, the present invention includes a probe 1, a probe holder 2, a probe holder clamp 3, a first adapter plate 4, a single-axis sub-nanometer positioning system 5, a second adapter plate 6, and a micro-operation platform 7. Sliding ruler support frame 8, sliding ruler 9, third adapter plate 10, U-shaped frame 11, liquid container 12, three thread adapters 13, two Luer two-way valves 14, syringe 15 and three pieces of medical silicone Tube 16.

[0034] Such as figure 1 , figure 2 As shown, the sliding ruler support frame 8 is vertically fixed on the workbench, and the sliding ruler 9 is installed on the side of the sliding ruler support frame 8 (such as Figure 4 shown), the third adapter plate 10 is fixed on the mobile platform of the sliding ruler 9 (as Figure 8 shown), the bottom surface of the U-shaped frame 11 is fixed on the thir...

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Abstract

The invention discloses a water pressure based sub-nano level single cell movement control system. A support frame is vertically fixed on a work bench, a sliding ruler is installed on the side surface of the support frame, a U shaped frame is fixed on the movable table of the sliding ruler through a third connection board; a liquid container is installed in the U shaped frame, two thread connector of upper cover of the liquid container are respectively connected to a two-way valve through a silicone tube, the third thread connector of the lower cover of the liquid container is connected to one end of a probe holder, the other end of the probe holder is provided with a probe; the probe holder is arranged in the spring slot of a probe holder clamp, and the probe holder clamp is fixed on the side surface of a uniaxial sub-nano positioning system through a first connection board and is fixed on a three dimensional micro operation platform through a second connection board. The tri-axial precision is 7 nm, the uniaxial distance is 20 mm, the cells are stably controlled, the damage to live cells is little, the closed loop precision of the uniaxial sub-nano positioning system is 0.05 nanometer, the distance is 12 micrometers, and the provided system is used to precisely control the movement of single cells and can be easily combined with a single cell micro operation system.

Description

technical field [0001] The invention relates to a single-cell microscopic operating system, in particular to a sub-nanometer single-cell motion control system based on water pressure. Background technique [0002] The combination of engineering and biomedicine can solve many problems that cannot be solved by traditional biological methods. It is an important way to combine engineering and biomedicine to apply the methods of research problems in the field of engineering to the research of biology. With the development of biophysical methods in recent years, many novel and efficient methods have gradually become important tools in biomedical research. There are often no integrated products in the market for these emerging systems, but users can skillfully integrate the formed sub-modules into the new system according to their needs. [0003] The control of cell movement is the basis of many research methods in the field of biomechanics, but the complete precise control subsys...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M1/00
CPCC12M33/04
Inventor 陈伟安宸毅
Owner ZHEJIANG UNIV
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