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Method and system for determining a bacterial resistance to an antibiotic drug

A technology for antibiotics and antibiotics, applied in bioinformatics, special data processing applications, instruments, etc.

Inactive Publication Date: 2016-05-18
ARES GENETICS GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, due to viral genome size, the content of genetic information for viruses is significantly smaller than that for bacteria, making traditional sequencing approaches unapplicable to address this complex problem for determining bacterial drug resistance.

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  • Method and system for determining a bacterial resistance to an antibiotic drug

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Embodiment Construction

[0046] Additional details, features, characteristics and advantages of the objects of the invention are also disclosed in the following description and in the accompanying accompanying drawings of the accompanying drawings, which show in exemplary form a preferred embodiment of the invention. However, these examples should in no way be construed as limiting the scope of the invention.

[0047] Figure 1 shows a system diagram of an exemplary embodiment of the system of the present invention.

[0048]In Fig. 1, the exemplary embodiment of the system for carrying out the method of the present invention comprises local client (1,2,4) and has stored the remote database (3) of a plurality of bacterial reference nucleic acid sequences, wherein, at least Some reference nucleic acid sequences are associated with corresponding antibiotic drug resistance information. The local client comprises means (1) for entering or receiving bacterial nucleic acid sequence information obtained from ...

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Abstract

The invention relates to a method, a databank, a system and a computer program product for determining a bacterial resistance to an antibiotic drug. A data bank is provided which comprises a plurality of bacterial reference nucleic acid sequences, wherein at least some reference nucleic acid sequences are associated with a respective antibiotic drug resistance information. A comparison unit is used for comparing said bacterial nucleic acid sequence information obtained from a sample with said plurality of bacterial reference nucleic acid sequences.

Description

technical field [0001] The present invention relates to a method, database, system and computer program product for determining bacterial resistance to antibiotic drugs. Background technique [0002] For many human infections, it is important to know early on which bacterium is the cause of the infection because the symptoms may be similar between different specimens and the cause and treatment of the infection may vary widely. [0003] Even more important is the immediate use of diagnostics to know the potential resistance and susceptibility profiles of certain bacteria, given the complexity of antibiotic resistance, a grand challenge ranging from multiple factors to single nucleotide level variations . [0004] Thus, traditional microbial segmentation migrated to molecular microbiology. [0005] Different approaches can be used for bacterial diagnosis, the gold standard being the isolation and growth of bacterial strains, which is time consuming. For antibiotic suscepti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/22G06F19/18G16B30/10G16B20/20
CPCG16B30/00G16B20/00G16B30/10G16B20/20
Inventor A·凯勒C·F·施特勒尔G·伦森
Owner ARES GENETICS GMBH
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