Extraction method and application of anticancer active monomer in curcuma

A technology of anti-cancer activity and extraction method, which is applied in the direction of organic active ingredients, medical preparations containing active ingredients, anti-tumor drugs, etc., and can solve the difficulties in ensuring the effectiveness of clinical medication, safety and sustainability, and lack of effective substances Basic and pharmacodynamic research, complex volatile oil components of zedoary, etc., to achieve good separation, high batch-to-batch consistency, and good biological activity
CN105601598BActive Publication Date: 2017-12-19TIANJIN YAOYU BIOLOGICAL TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN YAOYU BIOLOGICAL TECH
Publication Date
2017-12-19

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Abstract

The invention provides an extraction method of an anticancer active monomer in Curcuma zedoaria. The method includes: taking Curcuma zedoaria tuber as the raw material, grinding the Curcuma zedoaria tuber into powder, then conducting ethanol extraction, concentrating the filtrate, then dissolving the product in a n-hexane-ethanol mixed solvent; conducting one-dimensional liquid chromatography separation: employing a normal phase silica gel chromatographic column, adopting a binary mobile phase with n-hexane as the phase A and ethanol as the phase B, carrying out elution with the phase B at a concentration of 0-50%, and collecting the 15.5-17min eluent; performing dissolving with the n-hexane-ethanol mixed solvent; conducting two-dimensional liquid chromatography separation: employing an Acchrom X-Amide chromatographic column, adopting a binary mobile phase with n-hexane as the phase A and ethanol as the phase B, carrying out elution with the phase B at a concentration of 0-30%, and collecting the 17-18min eluent so as to obtain a target product. The invention provides a new compound never reported before, the process has the characteristics of simplicity, low cost, large preparation capacity and good repeatability, and the obtained monomer compound has high purity, good biological activity and anticancer drug development potential.
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Description

technical field

[0001] The invention relates to the technical field of pharmaceutical products, in particular to a method for extracting anticancer active monomers from the tuber of the traditional Chinese medicine Curcuma radix, and the application of the extracted anticancer active monomers in the preparation of anti-liver cancer and anti-lung cancer drugs. Background technique

[0002] Curcuma curcuma, a traditional Chinese medicine, is the rhizome of the ginger family, turmeric. Modern pharmacological studies have shown that the volatile oil of Curcuma curcuma has anti-tumor and antibacterial effects; Curcuma has anti-tumor effects and anti-early pregnancy effects. In addition, Curcuma curcuma has a significant effect on cardiovascular, gastrointestinal smooth muscle, acute renal failure, and also has a liver-protecting effect.

[0003] At present, the application of traditional Chinese medicine Curcuma radix is ​​mainly used for its volatile oil injection and compound ...

Claims

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