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Screening method for hemostatic and antibacterial Chinese herbal medicine and toothpaste formula

A hemostatic antibacterial and screening method, which is applied in the direction of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of low content of active ingredients, reducing the ability of oral tissues to heal themselves from damage, and antibacterial active ingredients targeting gender issues

Inactive Publication Date: 2016-05-25
GUANGXI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a screening method of hemostatic and antibacterial Chinese herbal medicine and a toothpaste formula to solve the lack of substantial and effective theoretical support and data support in the prior art; the traditional Chinese medicine toothpaste contains many traditional Chinese medicine prescriptions and complex composition, resulting in low active ingredient content; The antibacterial active ingredients are poorly targeted, and long-term use will easily reduce the self-healing ability of oral tissues to damage and other problems

Method used

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  • Screening method for hemostatic and antibacterial Chinese herbal medicine and toothpaste formula
  • Screening method for hemostatic and antibacterial Chinese herbal medicine and toothpaste formula
  • Screening method for hemostatic and antibacterial Chinese herbal medicine and toothpaste formula

Examples

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preparation example Construction

[0085] 2.1 Preparation of anticoagulant blood: take blood from rabbit ear vein, and mix gently with 3.8% sodium citrate solution at a volume ratio of 9:1. Centrifuge the anticoagulated blood at 1000r / min for 10min to prepare platelet-rich plasma, and centrifuge at 3000r / min for 10min to prepare platelet-poor plasma.

[0086] 2.2 Preparation of sample solution

[0087] Obtaining Chinese herbal medicine extracts: Weighing cypress leaves, notoginseng, mugwort leaves, angelica, salvia miltiorrhiza, Yunnan Baiyao, bletilla striata, thistle, purple pearl grass, astragalus, ginkgo biloba, tranexamic acid, honeysuckle, red peony root, thistle, Rhubarb, Rhizoma Imperatae, Rubia, Agrimony, and Puhuang Chinese herbal medicine samples are appropriate, soaked in deionized water at a ratio of 1:10 for 2 hours at room temperature, refluxed twice for 2 hours each time, filtered residues were ultrasonically extracted for 40 minutes, and the filtrates were combined and concentrated by rotary ev...

Embodiment 4

[0166] Example 4 In vitro hemostasis experiment

[0167] The steps of the experimental method refer to the above in vitro hemostatic experiment, and the results are shown in Table 8.

[0168] Table 85 coagulation index test results

[0169]

Embodiment 5

[0170] Embodiment 5 in vitro antibacterial experiment

[0171] The experimental method steps refer to the above in vitro hemostasis experiment, wherein the sample solution is prepared as follows:

[0172] Take Chinese herbal toothpaste samples 1-3, blank paste, Yunnan Baiyao toothpaste, and Liangmianzhen gum nourishing toothpaste and 2g of deionized water to a 1mL volumetric flask to obtain a 2g / mL Chinese herbal toothpaste sample solution. The sample solution was diluted twice with BHI liquid medium. After dilution, the drug concentration was 1, 0.5, 0.25, 0.125, 0.0625, 0.0313, 0.0156, 0.0078, 0.0039, 0.00195g / mL.

[0173] The antibacterial activity of different sample solutions to the experimental bacteria, the results are shown in Table 9.

[0174] Table 9 sample liquid is to the antibacterial result of two strains of oral pathogenic bacteria

[0175]

[0176] Bring the data in Table 8 and Table 9 into the model to obtain the comprehensive hemostasis evaluation result...

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Abstract

The invention discloses a screening method for hemostatic and antibacterial Chinese herbal medicine and a toothpaste formula, and belongs to the technical field of Chinese herbal medicine toothpaste preparation. The screening method for the Chinese herbal medicine comprises the first step of establishing an assessment index system, the second step of determining assessment index weights and checking consistency, and the third step of conducting quantification processing through fuzzy comprehensive judgment and conducting screening to obtain hemostatic and antibacterial Chinese herbal medicine. The toothpaste formula comprises 1-3.2% of Chinese herbal medicine, 64.8-66.1% of auxiliaries, and the balance deionized water, wherein the sum of weight percents of Chinese herbal medicine, auxiliaries and deionized water is 100%. By means of the Chinese herbal medicine toothpaste, a protection film can be formed on the gingival, the gingival can be protected for a long time, and the resistance to sensibility of the gingival can be improved. Compared with ordinary chemical toothpaste, the Chinese herbal medicine toothpaste has the advantages that smell is good, and decayed teeth, gum bleeding and other oral cavity problems can be remarkably eased, relieved and prevented when used for a long time.

Description

【Technical field】 [0001] The invention relates to a toothpaste for auxiliary treatment of oral inflammation, in particular to a screening method of hemostatic and antibacterial Chinese herbal medicine and a toothpaste formula. 【Background technique】 [0002] Among oral diseases, periodontal disease and dental caries are common and frequently-occurring diseases in the human oral cavity, and the growth of oral bacteria is the main factor causing such diseases. Usually, by adding functional ingredients in the toothpaste, the toothpaste has the function of assisting in the prevention, prevention and alleviation of oral problems or has a certain improvement effect on the condition of the teeth. [0003] There are many factors that affect gum bleeding, and a large part of the reason is caused by inflammation caused by oral anaerobic bacteria. There are many types of bacteria in the oral cavity, the most important ones are Streptococcus and Bacteroides melanogenes, among which Stre...

Claims

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Application Information

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IPC IPC(8): G01N33/86G01N33/49A61K8/97A61Q11/00A61Q17/00A61P7/04A61P31/04A61P29/00A61P1/02
CPCG01N33/86A61K8/97A61K36/14A61K36/232A61K36/258A61K36/282A61Q11/00A61Q17/005G01N33/49A61K2300/00
Inventor 廖丹葵宋瑾林钻煌覃青云伍善广李玲许静杨卫豪黄光伟孙建华周利琴黄华来卢凯玲廖彭莹孙丽霞
Owner GUANGXI UNIV
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