Stress loading device and system for constructing stress fracture animal model and method

Abstract

The invention discloses a stress loading device and system for constructing a stress fracture animal model and a method, and belongs to the technical field of animal experiment models. The device comprises a tissue fixing unit for fixing experimental animal skeletons, a laser displacement sensor is arranged at one side of the tissue fixing unit, and a stress sensor is arranged at the other side of the tissue fixing unit. A linear actuator is arranged at the other end of the stress sensor, and the tissue fixing unit, the stress sensor and the linear actuator are coaxially arranged. A linear guide rail is further arranged below the tissue fixing unit. The invention further discloses a controllable stress fracture animal model construction system based on the stress loading device. The system comprises the stress loading device, a real-time data collecting and processing module and a PC side LabVIEW control program. The device is precise and controllable in loading strength and time, and the success rate of establishment of the model can be effectively increased.

Description

Technical field [0001] The invention belongs to the technical field of animal experimental models, and specifically relates to a stress loading device, a loading system and a method for constructing a stress fracture animal model. Background technique [0002] Stress fracture (SF) is a kind of fatigue fracture that often occurs in normal bones. After the muscles are overused and fatigued, they cannot absorb the vibrations caused by repeated collisions in time, and the stress is transmitted to the bones, which can only be found under a microscope. Micro damage. If this kind of micro-injury accumulates and exceeds the body's ability to repair itself, stress fractures will occur. Stress fractures are common in military training and training of athletes and dancers. It is not only the focus and difficulty of military medicine research, but also one of the key research topics of sports medicine. [0003] In 1855, Breihaupt officially published an article about stress fractures in the ...

AI Technical Summary

Problems solved by technology

However, the tensile loading mode is difficult to simulate the occurrence and development of stress fractures under physiological conditions

In addition, all current stress fracture modeling methods require anesthesia of experimental animals, which is even more out of touch with the real occurrence of stress fractures

[0006] Clinical basic research requires easy-to-obtain and standardized animal models. However, the current foreign modeling methods are cumbersome and time-consuming due to the need for anesthesia. The domestic modeling methods all indirectly exert stress on the bones by stimulating animal muscle overload exercise. , since the starting point of stimulation is different each time, the quality of the model may be uneven, and the positive rate and standardization of the model cannot meet the requirements

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