New uses of itraconazole

A technology of itraconazole and its use is applied in the new use field of itraconazole to achieve the effects of inhibiting endothelial cell proliferation and migration ability and good medicinal value

Active Publication Date: 2020-04-07
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0008] So far, there is no information about the use of itraconazole as the active ingredient, or the pharmaceutical composition containing itraconazole, for the treatment of hemangiomas, especially infantile hemangiomas, hemangioendotheliomas, hemangioperictheliomas, glomus tumors, vascular hemangiomas, etc. Reports on hypervascular and malignant proliferation diseases such as sarcoma, angiofibroma, angiolipoma, angiokeratoma, plexiform hemangioma, verrucous hemangioma, spider angioma, senile hemangioma or Kaposi's sarcoma

Method used

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  • New uses of itraconazole
  • New uses of itraconazole
  • New uses of itraconazole

Examples

Experimental program
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Embodiment Construction

[0043] The experimental methods described in the following examples, unless otherwise specified, are conventional methods; the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0044] 1. Observation on the clinical efficacy of itraconazole in the treatment of infantile hemangioma

[0045] On November 23, 2011, the inventor encountered a 2-month-old baby girl (weight 4kg) in the dermatology clinic, who went to the doctor 10 days after birth due to hemangioma and ulcer formation between the left buttock and thigh. figure 1 -A shown. Fungal hyphae were found by direct microscopic examination of the secretions on the surface of the ulcer, and yeast-like colonies were grown by culture. It was identified as Candida albicans by CHROMagar color culture and molecular biology (using ITS1 / 4 primers for PCR amplification and product sequence analysis) (Candida albicans, GenBank accession number KC176533), diagnosed as infantile hemangioma ulce...

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Abstract

The present invention belongs to the field of pharmaceuticals, and relates in particular to a new use of itraconazole, specifically a new use of itraconazole in the preparation of a drug treating hemangiomas. The utilisation of itraconazole to treat hemangiomas effectively inhibits hemangioma endothelial cell proliferation and migration capability, has a good medicinal value, and provides a new option for the clinical treatment of hemangiomas, especially strawberry hemangiomas, cavernous hemangiomas, tufted hemangiomas, verrucous hemangiomas and mixed hemangiomas, hemangiomas of various organs of the body such as hepatic hemangiomas, splenic hemangiomas and cerebral hemangiomas, hemangioendotheliomas, hemangiopericytomas, paragangliomas, hemangiosarcomas, angiofibromas, angiolipomas, angiokeratomas, spider nevi, vascular malformations and telangiectasias, and excessive and malignant proliferative diseases of blood vessels such as infantile hemangiomas, adult hemangiomas, senile hemangiomas and Kaposi's sarcomas.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of itraconazole. Background technique [0002] Itraconazole is a synthetic high-efficiency, broad-spectrum, oral (capsule and oral liquid) or intravenous (injection) triazole antifungal drug. Formula -4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazole-1-methyl)-1, 3-dioxolan-4-yl]methoxy]phenyl]-1-piperazine]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1, 2,4-Triazol-3-one, the molecular formula is C 35 h 38 Cl 2 N 8 0 4 , molecular weight: 705.64, CAS number: 84625-61-6. Itraconazole capsule preparation is off-white pellet-like granules; odorless and tasteless; itraconazole oral liquid preparation is light yellow or yellow viscous clear liquid with cherry flavor. Itraconazole injection is a colorless to slightly yellow clear liquid. This product is soluble in lipids and almost insoluble in water. The molecular structure of itraconazole is as fol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61P35/00A61P35/04
CPCA61K31/496A61K9/06A61K9/08A61K9/14A61K9/20A61K9/48
Inventor 冉玉平
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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