Preparation method of self-adhesive skin repairing hydrogel

Abstract

The invention discloses a preparation method of self-adhesive skin repairing hydrogel. The preparation method includes subjecting natural chitosan to quaternary amine modification to enable the natural chitosan to have excellent bactericidal performance; preparing BSA (bull serum albumin) nano-particles embedded with growth factors promoting skin regeneration through desolvation; grafting dopamine into a natural gelatin material; crosslinking the quaternary amine modified chitosan, the growth factor embedded BAS nano-particles and the dopamine grafted gelatin to form a hydrogel material. The hydrogel material has multiple functions of adhesion, bacteria inhibition and skin wound healing promotion, thereby being used for skin repairing.

Description

technical field

[0001] The invention belongs to the field of bioengineering materials, especially skin repair materials. Background technique

[0002] The skin is the largest organ of the human body. A large area of ​​skin tissue exposed to the external environment may be damaged at all times. Burns, mechanical trauma, and ulcers caused by chronic diseases (such as diabetes) are the main causes of skin defects and loss of function. Extensive burns, chronic skin ulcers, skin cancer, diabetic ulcers, bedsores, etc. can often be treated with skin grafts. However, for various diseases such as extensive burns, sufficient skin is required for repair, and there is often a problem of insufficient skin donor sites. Therefore, it is of great significance to develop skin repair products that can effectively promote wound healing and skin tissue regeneration.

[0003] The primary function of the skin is to isolate body tissues from the external environment and act as a protective barr...