Application of Yiganle tablets in preparing medicine for inhibiting cell proliferation of ileocecum adenocarcinoma cell HCT-8
A technology of HCT-8, cecal adenocarcinoma, applied in the direction of drug combination, anti-tumor drug, pharmaceutical formulation, etc., can solve the problems of backwardness, many impurities, affecting clinical application, etc.
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Embodiment 1
[0024] Take 200g of chicken vine, 160g of knotweed, 200g of verbena, 200g of June snow, 200g of Malan grass, 200g of berry, 170g of auspicious grass, 100g of Gonggong wood, and 70g of cold water flower, and add it to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 750min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.30g.
[0025] After testing, the content of emodin in the finished product is 1.85mg / tablet.
Embodiment 2
[0027] Take 200g of chicken vine, 160g of Polygonum cuspidatum, 200g of verbena, 200g of June snow, 200g of Malan grass, 200g of Mao berry, 170g of auspicious grass, 100g of Gonggong wood and 70g of cold water flower, and add it to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 900min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.30g.
[0028] After testing, the content of emodin in the finished product is 1.21mg / tablet.
Embodiment 3
[0030] Take 200g of chicken vine, 160g of knotweed, 200g of verbena, 200g of June snow, 200g of Malan grass, 200g of berry, 170g of auspicious grass, 100g of Gonggong wood, and 70g of cold water flower, and add it to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 60°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 800min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.30g.
[0031] After testing, the content of emodin in the finished product is 0.95mg / tablet.
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