Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition of etodolac and medical application thereof

A technology of etodolac and its composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems that have not yet been reported on acute pharyngitis, achieve outstanding substantive features, and improve therapeutic effects Effect

Inactive Publication Date: 2016-06-29
周俭
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between etodolac and its pharmaceutical composition and acute pharyngitis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition of etodolac and medical application thereof
  • Pharmaceutical composition of etodolac and medical application thereof
  • Pharmaceutical composition of etodolac and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (Ⅰ) isolation preparation and structure confirmation

[0021] Reagent sources: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane are of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd., methanol, of analytical grade, purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0022] Separation method: (a) Crush Dendrobium (2kg), heat reflux extraction with 75% ethanol (20L×3 times), combine the extracts, concentrate until there is no alcohol smell (4L), and use petroleum ether (4L×3 times) in turn Extract with ethyl acetate (4L×3 times) and water-saturated n-butanol (4L×3 times) to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) The medium n-butanol extract was decontaminated with D101 macroporous resin, first eluted with 15% ethanol for 6 column volumes, then eluted with 70% ethanol for 10 column volumes, collected 70% eluate, and concentrated under ...

Embodiment 2

[0026] Example 2: Pharmacological effects

[0027] In this example, an acute pharyngitis animal model was established by spraying ammonia water on the pharynx of rats for 3 consecutive days, and the number of neutrophils, serum interleukin-1β (IL-1β) and interleukin-6 (IL- 6) and the expression of tumor necrosis factor-α (TNF-α), and observe the therapeutic effect of drugs on acute pharyngitis.

[0028] 1. Materials and methods

[0029] 1.1 Animals

[0030] Wistar rats, weighing (250±20) g, half male and half male, were provided by Shanghai Slack Laboratory Animal Co., Ltd.

[0031] 1.2 Reagents and samples

[0032] Etodolac was purchased from the National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Dexamethasone acetate tablets (Shanghai Xinyi Pharmaceutical Co., Ltd.). Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) enzyme-linked immunoassay kits (a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a pharmaceutical composition of etodolac and its medical use. The pharmaceutical composition of etodolac provided by the invention contains etodolac and a novel natural product compound (I), etodolac 1. When compound (I) acts alone, it has a therapeutic effect on acute pharyngitis; when etodolac and compound (I) act in combination, the therapeutic effect on acute pharyngitis is further improved, and it can be developed into a medicine for the treatment of acute pharyngitis. It has outstanding substantive features and notable progress compared with other products.

Description

Technical field [0001] The invention belongs to the field of biomedicine, and relates to a new use of etodolac, in particular to a pharmaceutical composition of etodolac and its application in acute pharyngitis. Background technique [0002] Etodolac is a non-steroidal anti-inflammatory drug that can relieve the symptoms and signs of osteoarthritis (degenerative joint disease) and rheumatoid arthritis. Relieve pain symptoms. Rheumatoid arthritis, including bone defect (erosion), joint cavity narrow, osteoarthritis (degenerative joint disease) and mild to moderate pain. [0003] So far, there has been no report on the correlation between etodolac and its pharmaceutical composition and acute pharyngitis. Summary of the invention [0004] The purpose of the present invention is to provide a pharmaceutical composition of etodolac, which contains etodolac and a natural product, and etodolac and the natural product can synergistically treat acute pharyngitis. [0005] The above objective...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/407A61K31/11A61P29/00A61P11/04C07C47/445C07C45/79
CPCA61K31/407A61K31/11A61K36/8984C07C45/79C07C47/445
Inventor 周俭
Owner 周俭
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com