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Counter-current chromatographic separation column and chromatographic instrument on basis of 3D (three-dimensional) printing

A countercurrent chromatography and 3D printing technology, which is applied in the field of countercurrent chromatography separation columns and chromatographs, can solve the problems of limited development functions of countercurrent chromatographic columns, difficult innovation of pipeline structure, easy damage of pipelines, etc., and improve the separation efficiency of countercurrent chromatography , increase the interaction force and mixing force of the solution, and improve the effect of distribution efficiency

Inactive Publication Date: 2016-07-06
SHANDONG ANALYSIS & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The countercurrent chromatography separation column with this structure is limited by commercial polytetrafluoroethylene tubes, and it is difficult to innovate in the pipeline structure. limit
At the same time, due to the direct friction between the PTFE pipeline and the support during the winding process, the pipeline is easily damaged and leaks. In addition, when the pipeline is relatively long, the volume of the countercurrent chromatographic separation column after winding will be very large. Big

Method used

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  • Counter-current chromatographic separation column and chromatographic instrument on basis of 3D (three-dimensional) printing
  • Counter-current chromatographic separation column and chromatographic instrument on basis of 3D (three-dimensional) printing
  • Counter-current chromatographic separation column and chromatographic instrument on basis of 3D (three-dimensional) printing

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Experimental program
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Effect test

Embodiment 1

[0026] The structure of the present invention is as figure 2 , image 3 As shown in the figure, the 3D printed countercurrent chromatography separation column has an integrated structure of the pipeline and the support column by 3D printing technology.

[0027] Further, the countercurrent chromatographic separation column 1 is a columnar structure, and a cylindrical protrusion coaxial with the columnar structure is provided at the center of the top and bottom of the columnar structure, and a columnar structure and two cylindrical protrusions are provided along the center of the cylindrical protrusion. The central axis perforation 2 in the center of the shaped protrusion is provided with central axis fixing screw perforations 3, 6, 7, 8, 9 on the sides of the two cylindrical protrusions; the sample inlet 4 is provided on the cylindrical protrusion at the top, There are multiple circles of cylindrical channels 10 used to replace the original pipelines in the columnar structure...

Embodiment 2

[0032] A chromatograph, the countercurrent chromatographic separation column adopts the 3D printed countercurrent chromatographic separation column designed in Example 1.

[0033] Aiming at the technical difficulties existing in conventional countercurrent chromatography separation columns, the present invention develops a countercurrent chromatography separation column based on 3D printing, which can print out tube shapes of any structure through drawing software, and then directly print them through 3D printing technology, and because the tube The road and the supporting column are integrally formed by 3D printing technology, so when the length of the pipeline is as long as that of the prior art, the volume of the separation column of the present invention is obviously smaller than that of the prior art.

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Abstract

The invention discloses a 3D printing-based countercurrent chromatographic separation column and a chromatograph. The countercurrent chromatographic separation column is a columnar structure integrally formed by 3D printing technology, and multiple circles are arranged inside the columnar structure for transferring samples. And a cylindrical channel connected from end to end, one end of the columnar channel is a sample inlet, the other end is a sample outlet, and the side wall of the columnar channel is wavy. This 3D printed countercurrent chromatography separation column pipeline is not prone to liquid leakage and can withstand a wide temperature range during use.

Description

technical field [0001] The invention relates to a countercurrent chromatographic separation column used in a chromatograph, and specifically discloses a 3D printing-based countercurrent chromatographic separation column and a chromatograph. Background technique [0002] Conventional countercurrent chromatography separation columns are composed of polytetrafluoroethylene tubes and pipeline supports, for example: the countercurrent chromatography separation columns disclosed in patents with patent numbers 02250372.2, 89221310.8, 201020002148.6, 201120031345.5, 201220647532.4, which include a pipeline support 1 -1 and the polytetrafluoroethylene pipeline 1-2 wound on the pipeline support body 1-1, and the outer layer of the pipeline is fixed with glue, and a plastic or metal shell is placed on the outermost pipeline friction. The countercurrent chromatography separation column with this structure is limited by commercial polytetrafluoroethylene tubes, and it is difficult to in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/22
CPCB01D15/22
Inventor 王晓王岱杰耿岩玲赵恒强于金倩贾文婷
Owner SHANDONG ANALYSIS & TEST CENT
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